Creation of molecular therapy for gastrointestinal cancer using inhibition of intra cellular molecular transport and regulation of epigenetics

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390351
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Chiba University
• Principal Investigator: MATSUBARA Hisahiro Chiba University, 大学院・医学研究院, 教授 (20282486)
• Co-Investigator(Kenkyū-buntansha): AKUTSU Yasunori 千葉大学, 大学院・医学研究院, 講師 (00375677)
• Project Period (FY): 2008 – 2010
• Keywords: 消化器癌 / 細胞内分子移動 / エピジェネティクス / 分子治療 / micro RNA

Research Abstract

In order to create new molecular therapy for gastrointestinal cancer, we have planed the regulation of gene transduction, translation and protein synthesis. Furthermore, we have tried inhibition of intracellular molecular transport for the same purpose. We found that new molecule which inhibit enzyme for genetic expression have good efficieny for gene therapy. And this molecule was revealed anti-tumor action. The regulation of molecular transportation between nuclear and cytoplasm have induced cell death. These new molecules are important seeds for translational research and extremely useful for new development of molecular therapy for gastrointestinal cancer.

Research Products

• [Journal Article] COX2 Expression Predicts Resistance To Chemoradiotherapy in Esophageal Squamous Cell Carcinoma. (2011)
  • Author(s): Akutsu Y, Hanari N, Yusup G, Komatsu-Akimoto A,Ikeda N, Mori M, Yoneyama Y, Endo S, Miyazawa Y, Matsubara H
  • Journal Title: Ann Surg Oncol.
• [Journal Article] Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma. (2011)
  • Author(s): Akutsu Y, Matsubara H, Kano M, Usui A, Yoneyama Y, Ikeda N, Komatsu A, Yusup G
  • Journal Title: Ann Surg Oncol. 18(3) Pages: 832-7
• [Journal Article] An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer. (2011)
  • Author(s): Wu D, Matsushita K, Matsubara H, Nomura F, Tomonaga T
  • Journal Title: Int J Cancer. 128(5) Pages: 1018-30
• [Journal Article] miR-145, miR-133a and miR-133b : Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. (2010)
  • Author(s): Kano M, Seki N, Kikkawa N, Fujimura L, Hoshino I, Akutsu Y, Chiyomaru T, Enokida H, Nakagawa M, Matsubara H
  • Journal Title: Int J Cancer. 127(12) Pages: 804-14
• [Journal Article] Recent advances in histone deacetylase targeted cancer therapy. (2010)
  • Author(s): Hoshino I, Matsubara H
  • Journal Title: Surg Today. 40(9) Pages: 809-15
• [Journal Article] CHAP31 induces apoptosis only via the intrinsic pathway in human esophageal cancer cells. (2010)
  • Author(s): Murakami K, Matsubara H, Hoshino I, Akutsu Y, Miyazawa Y, Matsushita K, Sakata H, Nishimori T, Usui A, Kano M, Nishino N, Yoshida M
  • Journal Title: Oncology. 78(1) Pages: 62-74
• [Journal Article] Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer. (2010)
  • Author(s): Kawahira H, Matsushita K, Shiratori T, Shimizu T, Nabeya Y, Hayashi H, Ochiai T, Matsubara H, Shimada H
  • Journal Title: Cancer Sci. 101(1) Pages: 289-91
• [Journal Article] Effects of carbon-ion radiotherapy combined with a novel histone deacetylase inhibitor, cyclic hydroxamic-acid-containing peptide 31 in human esophageal squamous cell carcinoma. (2009)
  • Author(s): Kano M, Yamada S, Hoshino I, Murakami K, Akutsu Y, Sakata H, Nishimori T, Usui A, Miyazawa Y, Kamada T, Tsujii H, Matsubara H
  • Journal Title: Anticancer Res. 29(11) Pages: 4433-8
• [Journal Article] Combined effects of p53 gene therapy and leptomycin B in human esophageal squamous cell carcinoma. (2008)
  • Author(s): Hoshino I, Matsubara H, Komatsu A, Akutsu Y, Nishimori T, Yoneyama Y, Murakami K, Sakata H, Matsushita K, Miyazawa Y, Brooks R, Yoshida M, Ochiai T
  • Journal Title: Oncology. 75(1-2) Pages: 113-9
• [Presentation] Fra-1 is an independent prognostic factor in esophageal squamous cell carcinoma and related to cell proliferation, migration and invasion in vitro. (2010)
  • Author(s): Matsubara H, Usui A, Akutsu Y, et al
  • Organizer: 22nd EORTC-NCI-AACR Symposium on MolecularTargets and Cancer Therapeutics
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2010-11-19
• [Presentation] CHAP31 Induces Apoptosis Only via the Intrinsic Pathway in Human Esophageal Cancer Cells. (2009)
  • Author(s): Matsubara H, Murakami K, Akutsu Y, Nishino N, Yoshida M
  • Organizer: 8th AACR-JCA Joint Conference
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2009-10-16
• [Presentation] 食道癌の外科治療と新規治療法の現況 (2008)
  • Author(s): 松原久裕
  • Organizer: 日本癌学会腫瘍別シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30