2010 Fiscal Year Final Research Report
Fundamental research for treatment strategy of pancreatic cancer by regulating multiple biological pathways
| Project/Area Number |
20390355
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
DOI Ryuichiro Kyoto University, 医学研究科, 非常勤講師 (20301236)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Yoshiya 京都大学, 医学研究科, 講師 (60359792)
MASUI Toshihiko 京都大学, 医学研究科, 助教 (20452352)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 膵臓外科学 |
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| Research Abstract |
TRAIL induces cancer cell apoptosis, but pancreatic cancer cells hava a mechanism to strongly avoid apoptosis. In this study, we tried to develop a strategy to induce apoptotic cell death by modifying the mechanism to avoid apoptosis in pancreatic cancer cells so that TRAIL can induce pancreatic cancer cell death. The mechanism to avoid apoptosis in pancreatic cancer cell is, in other words, a survival signal. Pancreatic cancer tissue strongly expresses survivin, an inhibitor of apoptosis. We have successfully developed oncolytic virus that acts only in cells expressing survivin.
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[Journal Article]2011
Author(s)
Shibuya K., Oya N., Fujii T., Doi R., Nakamura A., Matsuo Y., Mitsumori M., Hiraoka M.
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Journal Title
Am J Clin Oncol. 34(2)
Pages: 115-119
Peer Reviewed
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[Journal Article] Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan.2010
Author(s)
Ito T., Sasano H., Tanaka M., Osamura R.Y., Sasaki I., Kimura W., Takano K., Obara T., Ishibashi M., Nakao K., Doi R., et al.
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Journal Title
J Gastroenterol. 45 (2)
Pages: 234-243
Peer Reviewed
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[Journal Article] Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial.2010
Author(s)
Neoptolemos J.P., Stocken D.D., Bassi C., Ghaneh P., Cunningham D., Goldstein D., Padbury R., Moore M.J., Gallinger S., Mariette C., Wente M.N., Izbicki J.R. Friess H., Lerch M.M., Dervenis C., Olah A., Butturini G., Doi R., et al.
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Journal Title
JAMA. 304(10)
Pages: 1073-1081
Peer Reviewed
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[Journal Article] Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials.2009
Author(s)
Neoptolemos J.P., Stocken D.D., Tudur Smith C,. Bassi C., Ghaneh P., Owen E., Moore M., Padbury R., Doi R., Smith D., Buchler M.W.
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Journal Title
Br J Cancer 100(2)
Pages: 246-250
Peer Reviewed
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[Journal Article] Prognostic value of metastin expression in human pancreatic cancer.2009
Author(s)
Nagai K., Doi R., Katagiri F., Ito T., Kida A., Koizumi M., Masui T., Kawaguchi Y., Tomita K., Oishi S., Fujii N., Uemoto S.
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Journal Title
J Exp Clin Cancer Res. 28:9
Peer Reviewed
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[Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia.2009
Author(s)
Kanai M., Morita S., Matsumoto S., Nishimura T., Hatano E., Yazumi S., Sasaki T., Yasuda H., Kitano T., Misawa A., Ishiguro H., Yanagihara K., Ikai I., Doi R., Fukushima M.
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Journal Title
Ann Oncol 20(8)
Pages: 1397-401
Peer Reviewed
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[Journal Article] 膵部分切除2009
Author(s)
土井隆一郎
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Journal Title
Digestive Surgery Now No. 4 胆・膵外科標準手術-操作のコツとトラブルシューティング,メジカルビュー社.東京
Pages: 102-115
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[Journal Article] Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma.2008
Author(s)
Seo, S., Hatano, E., Higashi, T., Nakajima, A., Nakamoto, Y., Tada, M., Tamaki, N., Iwaisako, K., Mori, A., Doi R., Ikai, I., Uemoto, S.
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Journal Title
Surgery 143(6)
Pages: 769-77
Peer Reviewed
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[Journal Article] Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer.2008
Author(s)
Toyoda, E., Doi R., Kami, K., Mori, T., Ito, D., Koizumi, M., Kida, A., Nagai K., Ito, T., Masui, T., et al.
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Journal Title
J Exp Clin Cancer Res 27:30
Peer Reviewed
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[Journal Article] Adenovirus vectors with chimeric type 5 and type 35 fiber proteins exhibit enhanced transfection of humanpancreatic cancer cells.2008
Author(s)
Toyoda, E., Doi R., Kami, K., Mori, T., Ito, D., Koizumi, M., Kida, A., Nagai K., Ito, T., Masui, T., et al.
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Journal Title
Int J Oncol. 33(6)
Pages: 1141-7
Peer Reviewed
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[Presentation] S-1による膵管癌術後化学療法の検討2008
Author(s)
上和広, 土井隆一郎, 小泉将之, 増井俊彦, 安近健太郎, 小川晃平, 岩永康裕, 川口義弥, 江川裕人, 上本伸二
Organizer
第50回日本消化器病学会大会
Place of Presentation
東京
Year and Date
20081001-20081004
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[Presentation] 膵切除術後の重症合併症の治療とその発生防止対策2008
Author(s)
土井隆一郎
Organizer
第63回日本消化器外科学会総会,土井隆一郎,小川晃平,安近健太郎,泰浩一郎,岩永康裕,川口義弥,新田隆士,増井俊彦,江川裕人,上本伸二
Place of Presentation
札幌
Year and Date
20080716-20080718
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