2010 Fiscal Year Final Research Report
Development of cancer therapy using organelles-targeting nanocarrier
| Project/Area Number |
20390381
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University |
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Principal Investigator |
MIZUNO Masaaki Nagoya University, 医学系研究科, 准教授 (70283439)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMATO Shinji 名古屋大学, 大学院・医学系研究科, 助教 (30464142)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞 / ナノテクノロジー / 細胞内小器官 / がん / siRNA |
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| Research Abstract |
In this study, we developed nanocarrier for organelles based on the technologies using DEAE polymer and liposome, and succeeded to target a lot of organelles such as mitochondria, chromosome, and contractile ring. When binding siRNA to the nanocarrier, we could confirm he biological activities in in vitro and in vivo experiments. Also, we established the process to produe the siRNA binding nanocarrier under GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) control.
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[Journal Article] Neurosurgical robotic system for brain tumor removal.2010
Author(s)
Arata J^*, Tada Y, Kozuka H, Wada T, Saito Y, Ikedo N, Hayashi Y, Fujii M, Kajita Y, 水野正明, Wakabayashi T, Yoshida J, Fujimoto H.
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Journal Title
Int J Comput Assist Radiol Surg.
Peer Reviewed
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[Journal Article] Significant antitumor activity of cationic multi- lamellar liposomes containing human interferon- β gene in combination with 5-fluorouracil against human renal cell carcinoma.2008
Author(s)
Yamamoto K, Mizutani Y, Nakanishi H, Fujiwara J, Ishida H, Toiyama D, Abe K, Hayashi I, Okada K, Kawauchi A, 水野正明, Yoshida J, Miki T^*.
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Journal Title
Int.J Oncol 33
Pages: 565-571
Peer Reviewed
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[Journal Article] A pilot study of human interferon beta gene therapy for patients with advanced melanoma by in vivo transduction using cationic liposomes.2008
Author(s)
Matsumoto K, Kubo H, Murata H, Uhara H, Takata M, Shibata S, Yasue S, Sakakibara A, Tomita Y, Kageshita T, Kawakami Y, 水野正明, Yoshida J, Saida T^*.
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Journal Title
Jpn J Clin Oncol 38
Pages: 849-856
Peer Reviewed
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