2010 Fiscal Year Final Research Report
Identification of the novel molecular marker for oligodendroglial tumor using induced differentiation system against glioma stem cell.
| Project/Area Number |
20390387
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Miyazaki |
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Principal Investigator |
TAKESHIMA Hideo University of Miyazaki, 医学部, 教授 (70244134)
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| Co-Investigator(Kenkyū-buntansha) |
UEHARA Hisao 宮崎大学, 医学部, 准教授 (80203470)
YOKOGAMI Kiyotaka 宮崎大学, 医学部, 講師 (40284856)
YAMASHITA Shinji 宮崎大学, 医学部, 助教 (40468046)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌幹細胞 / 乏突起膠腫 / 分子マーカー / グリオーマ / 分化誘導 |
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| Research Abstract |
Malignant gliomas show dismal prognosis and glioma stem cell may play a pivotal role on this issue. We established glioma stem cell lines from surgical samples using spheroid method. Using these glioma stem cells, we biologically analyzed 2 novel molecules, N-myc downstream-related gene (NDRG) and EVI1. (1) Glioma stem cell did not express NDRG. However, after differentiation in response to serum, glioma cell strongly express NDRG. (2) EVI1 is a transcriptional factor. Knock-out mice show abnormality in central nervous system. We have shown that knock-down of EVI1 in glioma stem cell and found that Notch signal transduction system was strongly supressed. These novel findings might be important for establishing new treatment against malignant glioma.
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Research Products
(13 results)
