2011 Fiscal Year Final Research Report
Therapeutic benefits of the genetically-engineering mesenchymal stem cells for sub-acute cerebral ischemia
| Project/Area Number |
20390388
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HONMOU Osamu 札幌医科大学, 医学部, 教授 (90285007)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Hirofumi 東京薬科大学, 生命科学部, 教授 (00189614)
HOUKIN Kiyohiro 北海道大学, 大学院・医学研究科, 教授 (90229146)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 移植・再生医療 / 再生医学 / 神経科学 / 脳・神経 / 発生・分化 |
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| Research Abstract |
We have reported that transplantation of bone marrow stem cells has demonstrated therapeutic efficacy in animal models of acute cerebral ischemia. In the present study, we transplanted bone marrow stem cells into middle cerebral artery occlusion model rats to study their potential therapeutic benefit in the subacute phase. This work demonstrates that highly purified bone marrow stem cells are neuroprotective and angeigenetic in subacute cerebral ischemia models.
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Research Products
(42 results)
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[Journal Article] Expression of Aquaporin-4 Augments Cytotoxic Brain Edema after Traumatic Brain Injury during Acute Ethanol Exposure2011
Author(s)
Katada R, Nishitani Y, Honmou O, Mizuo K, Okazaki S, Tateda K, et al Katada R, Nishitani Y, Honmou O, Mizuo K, Okazaki S, Tateda K, et al
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Journal Title
Am J Pathol
Volume: 180
Pages: 17-23
Peer Reviewed
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