2010 Fiscal Year Final Research Report
Elucidation of osteoclastogenic signals in the aim of development of bone-resorption depressants
| Project/Area Number |
20390393
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INOUE Jun-Ichiro The University of Tokyo, 医科学研究所, 教授 (70176428)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 破骨細胞 / リウマチ / 骨粗鬆症 / RANK / 創薬 |
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| Research Abstract |
Excess activation or differentiation of born-resorbing osteoclasts results in exacerbation of osteoporosis and rheumatoid arthritis. To develop bone-resorption depressants, we analyzed osteoclastogenic signals and found that HCR (Highly Conserved domain in RANK) of the RANK receptor is crucial for differentiation of osteoclasts. We also identified the HCR-binding proteins that may function together with HCR to promote osteoclastogenesis. Moreover, we have already begun to search compounds that could be used as bone-resorption depressants by inhibiting osteoclastogenic signals through HCR using the chemical compound library.
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Research Products
(33 results)
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[Journal Article] Human lactoferrin activates NF-κB through Toll-like receptor 4 (TLR4) pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling.2010
Author(s)
Ando K., Hasegawa K., Shindo K., Furusawa,T., Fujino T., Kikugawa K., Nakano H., Takeuchi O., Akira S., Akiyama T., Gohda J., Inoue J., Hayakawa M.
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Journal Title
FEBS Journal 277
Pages: 2051-2066
Peer Reviewed
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[Journal Article] TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA andDNA.2009
Author(s)
Konno H., Yamamoto T., Yamazaki K., Gohda J., Akiyama T., Semba K., Goto H., Kato A Yujiri T Imai T., Kawaguchi Y., Su B., Takeuchi O., Akira S., Tsunetsugu-Yokota Y., Inoue J.
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Journal Title
PLoS ONE 4(5)
Pages: e5674
Peer Reviewed
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[Journal Article] Constitutive activation of NF-κB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines.2009
Author(s)
Yamaguchi N., Ito T., Azuma S., Ito E., Honma R., Yanagisawa Y., Nishikawa A., Kawamura M., Imai J., Watanabe S., Semba K., Inoue J.
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Journal Title
Cancer Sci. 100
Pages: 1668-1674
Peer Reviewed
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[Journal Article] Id2- RORγt- and LTβR-independent initiation of lymphoid organogenesis in ocular immunity.2009
Author(s)
Nagatake T., Fukuyama S., Kim D.Y., Goda K., Igarashi O., Sato S., Nochi T., Sagara H., Yokota Y., Jetten A.M., Kaisho T., Akira S., Mimuro H., Sasakawa C., Fukui Y., Fujihashi K., Akiyama T., Inoue J., Penninger J.M., Kunisawa J., Kiyono H.
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Journal Title
J Exp Med. 206
Pages: 2351-2364
Peer Reviewed
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[Journal Article] FoxA1 as a lineage-specific oncogene in luminal type breast cancer.2008
Author(s)
Yamaguchi N., Ito E., Azuma S., Honma R., Yanagisawa Y., Nishikawa A., Kawamura M., Imai J., Tatsuta K., Inoue J., Semba K., Watanabe S.
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Journal Title
Biochem. Biophys. Res. Commun 365
Pages: 711-717
Peer Reviewed
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[Journal Article] The Tumor Necrosis Factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.2008
Author(s)
Akiyama T., Shimo Y., Yanai H., Qin J., Ohsima D., Maruyama Y., Asaumi Y., Kitazawa J., Takayanagi H., Penninger JM., Matsumoto M., Nitta T., Takahama Y., Inoue J.
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Journal Title
Immunity 29
Pages: 423-437
Peer Reviewed
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[Journal Article] The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator.2008
Author(s)
Hikosaka Y., Nitta T., Ohigashi I., Yano K., Ishimaru N., Hayashi Y., Matsumoto M., Matsuo K., Penninger JM., Takayanagi H., Yokota Y., Yamada H., Yosikai Y., Inoue J., Akiyama T., Takahama Y.
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Journal Title
Immunity 29
Pages: 438-450
Peer Reviewed
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