2010 Fiscal Year Final Research Report
Enhancement of bone healing during distraction osteogenesis
| Project/Area Number |
20390401
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YASUI Natsuo The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Shinjiro 徳島大学, 病院, 准教授 (20284292)
MATSUURA Tetsuya 徳島大学, 病院, 講師 (30359913)
NIKAWA Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824)
TAKAHASHI Mitsuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10372715)
SAIRYO Koichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10304528)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 仮骨延長 / 骨成長因子 / 持続投与 / distraction / osteogenesis |
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| Research Abstract |
Rabbit tibial lengthening was achieved to examine the effect of local infusion of the growth factors and bisphosphonate into the lengthened segment. When FGF-2 and bisphosphonate were infused simultaneously during consolidation phase, bone healing was dramatically enhanced. FGF-2 stimulated bone formation while bisphosphonate inhibited bone resorption. We believe this method is valid to shorten the treatment time of limb lengthening and is applicable in the clinical field as a new drug delivery system.
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Author(s)
Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
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Ann Rheum Dis 69(2)
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Author(s)
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
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Mol Cell Biol 29(17)
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Author(s)
Yukata K, Matsui Y, Shukunami C, Takimoto A, Goto T, Nishizaki Y, Nakamichi Y, Kubo T, Sano T, Kato S, Hiraki Y, Yasui N
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Journal Title
Bone 43(2)
Pages: 1047-1056
Peer Reviewed
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