2011 Fiscal Year Final Research Report
Investigation of disorders of interaction between bone and bone marrow after intake of alcohol and fat
| Project/Area Number |
20390406
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAI Akinori 産業医科大学, 医学部, 准教授 (90248576)
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| Project Period (FY) |
2008 – 2011
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| Keywords | アルコール / 脂肪 / 骨芽細胞 / 骨髄細胞 / シグナル伝達 / p21 / アセトアルデヒド脱水素酵素 |
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| Research Abstract |
Disruption of Apo E gene with high fat diet resulted in trabecular bone loss and reduced bone formation at the secondary spongiosa of the tibia in mice. In these disrupted mice, apoptosis was induced in osteoblasts through enhanced expression of p53 mRNA and osteoblastic differentiation and proliferation were suppressed. Bone formation was decreased. Disruption of aldehyde-dehydrogenase 2 gene with alcohol intake resulted in trabecular bone loss and reduced bone formation in mice. Cell cycle arrest was induced through enhanced expression of p21 mRNA and osteoblastic mineralization was disturbed. Bone formation was decreased. Thus, we demonstrated the mechanism underlying trabecular bone loss induced by alcohol intake or high fat diet through cell cycle arrest or apoptosis of osteoblasts.
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Research Products
(15 results)
