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2010 Fiscal Year Final Research Report

Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging

Research Project

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Project/Area Number 20390407
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionEhime University (2010)
Japanese Foundation For Cancer Research (2008-2009)

Principal Investigator

IMAMURA Takeshi  Ehime University, 大学院・医学系研究科, 教授 (70264421)

Project Period (FY) 2008 – 2010
Keywordsバイオテクノロジー / シグナル伝達 / 酵素 / 生体分子 / 細胞・組織
Research Abstract

In order to clarify the roles of TGF-β/BMP signaling during angiogenesis in bone metastasis sites of breast cancer, we developed advanced in vivo optical imaging systems by which we can visualize tumor angiogenesis and TGF-β/BMP at the same time. In addition, we studied the effects of angiogenesis inhibitors and TGF-β/BMP signaling blockers during bone metastasis of breast cancer in vivo.

  • Research Products

    (25 results)

All 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Arkadia complexes with clathrin adaptor AP2 and regulates EGF signaling2010

    • Author(s)
      Mizutani A, Saitoh M, Imamura T, Miyazawa K, Miyazono K.
    • Journal Title

      J Biochem 148

      Pages: 733-741

    • Peer Reviewed
  • [Journal Article] Estrogen inhibits transforming growth factor b signaling by promoting Smad2/3 degradation2010

    • Author(s)
      Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J.
    • Journal Title

      J Biol Chem 285

      Pages: 14747-1455

    • Peer Reviewed
  • [Journal Article] Runx1 and Runx2 cooperate during sternal morphogenesis2010

    • Author(s)
      Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S.
    • Journal Title

      Development 137

      Pages: 1159-1167

    • Peer Reviewed
  • [Journal Article] TGF-b type II Receptor mRNA in Retinoblastoma Cell Lines is induced by Trichostatin A2010

    • Author(s)
      Kashiwagi Y, Horie K, Kanno C, Inomata M, Imamura T, Kato M, Yamamoto T, Yamashita H
    • Journal Title

      Invest Ophthalmol Vis Sci 51

      Pages: 679-685

    • Peer Reviewed
  • [Journal Article] Promoter-wide analysis of Smad4 binding sites in human epithelial cells2009

    • Author(s)
      Koinuma D, Tsutsumi S, Kamimura N, Imamura T, Aburatani H, Miyazono K
    • Journal Title

      Cancer Sci 100

      Pages: 2133-2142

    • Peer Reviewed
  • [Journal Article] Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells2009

    • Author(s)
      Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T
    • Journal Title

      Cancer Sci 100

      Pages: 2085-2092

    • Peer Reviewed
  • [Journal Article] Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation2009

    • Author(s)
      Kido S, Kuriwaka-Kido R, Imamura T, Ito Y, Inoue D, Matsumoto T.
    • Journal Title

      Bone 45

      Pages: 1125-1132

    • Peer Reviewed
  • [Journal Article] Role of Ras signaling in the induction of snail by TGF-b2009

    • Author(s)
      Horiguchi K, Shirakihara T, Nakano A, Imamura T, Miyazono K, Saitoh M
    • Journal Title

      J Biol Chem 284

      Pages: 245-253

    • Peer Reviewed
  • [Journal Article] ChIP-chip analysis of Smad2/3 binding sites reveals 1 roles of ETS1 and TFAP2A in TGF-β signaling2009

    • Author(s)
      Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H
    • Journal Title

      Mol Cell Biol 29

      Pages: 172-186

    • Peer Reviewed
  • [Journal Article] Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells2008

    • Author(s)
      Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T
    • Journal Title

      J Biol Chem 283

      Pages: 35660-35667

    • Peer Reviewed
  • [Journal Article] CCAAT/Enhancer-binding Protein b Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF42008

    • Author(s)
      Tominaga H, Maeda S, Hayashi M, Takeda S, Akira S, Komiya S, Nakamura T, Akiyama H, Imamura T
    • Journal Title

      Mol Biol Cell 19

      Pages: 5373-5386

    • Peer Reviewed
  • [Journal Article] Regulation of TGF-b family signaling by E3 ubiquitin ligases.2008

    • Author(s)
      Inoue Y, Imamura T
    • Journal Title

      Cancer Sci 99

      Pages: 2107-2112

    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway2008

    • Author(s)
      Katsuno Y, Hanyu A, Kanda H, Ishikawa Y, Akiyama F, Iwase T, Ogata E, Ehata S, Miyazono K, Imamura T
    • Journal Title

      Oncogene. 27

      Pages: 6322-6333

    • Peer Reviewed
  • [Presentation] 革新的インビボ光イメージングの骨代謝への応用2010

    • Author(s)
      今村健志
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      かがわ国際会議場(香川県)
    • Year and Date
      20100918-20100919
  • [Presentation] 光技術を駆使した細胞機能イメージングの骨研究への応用2010

    • Author(s)
      今村健志
    • Organizer
      第28回日本骨代謝学会学術集会シンポジウム10
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      20100721-20100723
  • [Presentation]2009

    • Author(s)
      今村健志
    • Organizer
      第32回日本分子生物学会年会. Recent progress of in vivo optical imaging of cancer
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2009-12-12
  • [Presentation] 乳がん骨転移におけるTGF-β/BMPシグナルの役割とインビボ光イメージング2009

    • Author(s)
      今村健志
    • Organizer
      第27回日本骨代謝学会学術集会シンポジウム1
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2009-07-23
  • [Presentation] 光イメージングを利用したがん研究新戦略2009

    • Author(s)
      今村健志
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2009-05-16
  • [Presentation] 生命のダイナミズム・不均一性・確率性・~個体で細胞を「みて」「知る」~2008

    • Author(s)
      今村健志
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市神戸ポートピホテル
    • Year and Date
      20081209-20081212
  • [Presentation] 骨と癌のインビボ光イメージング2008

    • Author(s)
      今村健志
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪府大阪市大阪国際会議場
    • Year and Date
      20081029-20081031
  • [Presentation] In vivo optical imaging of cancer and microenvironment.2008

    • Author(s)
      今村健志
    • Organizer
      第2回JCA-AACR合同カンファレンス-乳がん研究の最前線
    • Place of Presentation
      兵庫県淡路市淡路夢舞台国際会議場
    • Year and Date
      20080714-20080716
  • [Presentation] In vivo optical imaging of tumor microenvironment and TGF-β signaling2008

    • Author(s)
      今村健志
    • Organizer
      第28回札幌がんセミナー国際シンポジウム
    • Place of Presentation
      北海道札幌市北海道大学学術交流会館講堂
    • Year and Date
      20080627-20080628
  • [Presentation] がんの血管新生と細胞周期のインビボ光イメージング2008

    • Author(s)
      今村健志
    • Organizer
      第3回日本分子イメージング学会総会 学術集会
    • Place of Presentation
      埼玉県大宮市0大宮ソニックシティ
    • Year and Date
      2008-05-22
  • [Presentation] 癌の増殖転移における血管新生と骨破壊のインビボイメージング2008

    • Author(s)
      今村健志
    • Organizer
      第62回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡県福岡市福岡国際会議場
    • Year and Date
      2008-04-17
  • [Remarks] ホームページ等

    • URL

      http://www.m.ehime-u.ac.jp/medical/course/ProgramForMedicalSciences/

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Published: 2012-01-26   Modified: 2015-04-09  

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