2010 Fiscal Year Final Research Report
Analysis of inhaled anesthetics on the analgesic effect and immobilization in the spinal cord
| Project/Area Number |
20390414
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
KOHNO Tatsuro Niigata University, 医歯学系, 准教授 (00313536)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IKOMA Miho 新潟大学, 医歯学総合病院, 助教 (30432082)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TERUMASA Nakatsuka 佐賀大学, 医学部, 准教授 (30380752)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 脊髄 / 麻酔薬 / 鎮痛 / 不動化 |
|---|
| Research Abstract |
General anesthetics have the actions of hypnosis, amnesia, analgesia and immobility. To elucidate the effects of nitrous oxide and xenon in spinal dorsal horn neurons, we conducted the electrophysiological experiments. We revealed that nitrous oxide had no effects on the inhibitory synaptic transmission in dorsal horn neurons. In addition, xenon inhibited excitatory but not inhibitory transmission in dorsal horn neurons, leading to the antinociceptive effect.
|
