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2010 Fiscal Year Final Research Report

Translational research of animal study and clinical trial for the mechanisms of weather-dependent pain aggravation.

Research Project

  • PDF
Project/Area Number 20390415
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya University

Principal Investigator

SATO Jun  Nagoya University, 環境医学研究所, 准教授 (00235350)

Co-Investigator(Kenkyū-buntansha) USHIDA Takahiro  愛知医科大学, 医学部, 教授 (60304680)
Co-Investigator(Renkei-kenkyūsha) SAKURAI Hiroki  浜松大学, 保健医療学部, 講師 (60454419)
Project Period (FY) 2008 – 2010
Keywords慢性疼痛 / 気象 / うつ病 / 自律神経 / 内耳前庭
Research Abstract

The authors have clarified underlying mechanisms of weather-sensitive diseases, such as chronic pain and depression in the basic animal research. In the present research project, we have further progressed the animal study and had clinical study using chronic pain patients with their pain to be sensitive to weather change. This translational study succeeded to product human model of weather-sensitive pain and provided a scientific link between laboratory research and human trials, and the beginning of discovery of therapeutic strategies for this syndrome.

  • Research Products

    (11 results)

All 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Lowering barometric pressure aggravates depression-like behavior in rats2010

    • Author(s)
      MIZOGUCHI Hiroyuki, FUKAYA Kanoko, MORI Rarami, ITOH Mariko, FUNAKUBO Megumi, SATO Jun
    • Journal Title

      Behavioural Brain Research Vol.218

      Pages: 190-193

    • Peer Reviewed
  • [Journal Article] Increases in neuronal activity in rat spinal trigeminal nucleus following changes in barometric pressure-relevance for weather-associated headache2010

    • Author(s)
      MESSLINGER Karl, FUNAKUBO Megumi, SATO Jun, MIZUMURA Kazue
    • Journal Title

      Headache Vol.50, No.9

      Pages: 1449-1463

    • Peer Reviewed
  • [Journal Article] The inner ear is involved in the aggravation of nociceptive behavior induced by lowering barometric pressure of nerve injured rats2010

    • Author(s)
      FUNAKUBO Megumi, SATO Jun HONDA Takashi, MIZUMURA Kazue
    • Journal Title

      European Journal of Pain Vol.14, No.1

      Pages: 32-39

    • Peer Reviewed
  • [Presentation] 寒冷ストレスによる気分障害および慢性痛モデルラットの血中ノルアドレナリン量の変化2010

    • Author(s)
      佐藤純
    • Organizer
      第49回日本生気象学会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-05
  • [Presentation] 気圧低下曝露がラットの抑うつ行動に与える影響2009

    • Author(s)
      佐藤純
    • Organizer
      第48回日本生気象学会大会
    • Place of Presentation
      つくば
    • Year and Date
      2009-10-30
  • [Presentation] Exposure to low atmospheric pressure increases activity of rat spinal trigeminal nucleus neurons- relevance for weather-related headaches?2009

    • Author(s)
      SATO Jun
    • Organizer
      14th Congress of the International Headache Society
    • Place of Presentation
      USA
    • Year and Date
      2009-10-01
  • [Presentation] Weather change and pain : an animal study of the influences of simulated meteorological changes on automatic nervous system and chronic pain2008

    • Author(s)
      SATO Jun
    • Organizer
      18th International Congress of Biometeorology
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-09-23
  • [Book] からだと温度の辞典2010

    • Author(s)
      佐藤純, 他
    • Total Pages
      640(199-201)
    • Publisher
      朝倉書店
  • [Remarks] 佐藤純,読売新聞,くらし教育・健康プフス,2009.6.16

  • [Remarks] 佐藤純,読売新聞,くらし学び・健康プフス,2009.8.13

  • [Patent(Industrial Property Rights)] 人体の雰囲気の気圧を昇圧する方法及びその装置2010

    • Inventor(s)
      佐藤純, 櫻井博紀, 斎藤愛子
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      特許,特願2010-M8903
    • Filing Date
      2010-06-30

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Published: 2012-01-26   Modified: 2016-04-21  

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