2010 Fiscal Year Final Research Report
Clarification of mechanisms of antineoplastic drug-induced painful peripheral neuropathy in human patients with cancer
| Project/Area Number |
20390418
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NAMIKI Akiyoshi Sapporo Medical University, 名誉教授 (00136954)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
KIYA Tomohiro 札幌医科大学, 医学部, 研究員 (10438046)
NIIYAMA Yukitoshi 札幌医科大学, 医学部, 講師 (90423764)
SAWADA Atsushi 札幌医科大学, 医学部, 研究員 (10551492)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 悪性腫瘍 / 疼痛 / 化学療法 / L-セリン |
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| Research Abstract |
Paclitaxel is one of the most commonly used antineoplastic drugs for the treatment of solid tumors. It is often associated with painful peripheral neuropathy. However, the mechanisms have been elucidated. In this study, we examined the involvement of L-serine in paclitaxel-induced peripheral neuropathy. This study suggests that a decrease in satellite cell-derived in the dorsal root ganglion contributed to paclitaxel-induced painful peripheral neuropathy. And intraperitoneal administration of L-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia. The findings of this study may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy in human patients with cancer.
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