2010 Fiscal Year Final Research Report
The molecular function of immortalization-related genes in the regulation of Oncogenic Ras and prostatic carcinogenesis.
| Project/Area Number |
20390426
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
KUMON Hiromi Okayama University, 大学院・医歯薬学総合研究科, 教授 (30144760)
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| Co-Investigator(Kenkyū-buntansha) |
HUH Namho 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
MASAKIYO Sakaguchi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
NASU Yasutomo 岡山大学, 病院, 教授 (20237572)
TSUTSUI Ken 岡山大学, 自然生命科学研究センター, 教授 (70108158)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 不死化関連遺伝子 / Ras / Ras-GTP / Akt / BiP / GRP78 / 前立腺分化 |
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| Research Abstract |
We analyzed the molecular function of novel immortalization-related genes, which were identified at Okayama University, in the intracellular Ras signaling and cell growth of prostate normal and cancer cells. In particular, we disclosed that the expression of REIC/Dkk-3, one of the immortalization-related genes, inactivated Akt signaling by down-regulating activated Ras. We also elucidated that the expression of BiP/GRP78, one of molecular chaperones, suppresses the REIC/Dkk-3-induced apoptotic signaling.
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[Journal Article] Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development.2010
Author(s)
Zhang K, Watanabe M, Kashiwakura Y, Li SA, Edamura K, Huang P, Yamaguchi K, Nasu Y, Kobayashi Y, Sakaguchi M, Ochiai K, Yamada H, Takei K, Ueki H, Huh NH, Li M, Kaku H, Na Y, Kumon H.
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Journal Title
Int J Oncol. 37(6)
Pages: 1495-501
Peer Reviewed
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[Journal Article] REIC/Dkk-3 stable transfection reduces the malignant phenotype of mouse prostate cancer RM9 cells.2009
Author(s)
Chen J, Watanabe M, Huang P, Sakaguchi M, Ochiai K, Nasu Y, Ouchida M, Huh NH, Shimizu K, Kashiwakura Y, Kaku H, Kumon H.
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Journal Title
Int J Mol Med. 24(6)
Pages: 789-794
Peer Reviewed
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[Journal Article] Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.2009
Author(s)
Sakaguchi M, Kataoka K, Abarzua F, Tanimoto R, Watanabe M, Murata H, Than SS, Kurose K, Kashiwakura Y, Ochiai K, Nasu Y, Kumon H, Huh NH.
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Journal Title
J Biol Chem. 284(21)
Pages: 14236-14244
Peer Reviewed
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[Journal Article] Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.2009
Author(s)
Watanabe M, Kashiwakura Y, Huang P, Ochiai K, Futami J, Li SA, Takaoka M, Nasu Y, Sakaguchi M, Huh NH, Kumon H.
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Journal Title
Int J Oncol. 34(3)
Pages: 657-663
Peer Reviewed
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[Journal Article] REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer.2009
Author(s)
Kawasaki K, Watanabe M, Sakaguchi M, Ogasawara Y, Ochiai K, Nasu Y, Doihara H, Kashiwakura Y, Huh NH, Kumon H, Date H.
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Journal Title
Cancer Gene Ther. 16(1)
Pages: 65-72
Peer Reviewed
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[Journal Article] Mechanistic analysis of resistance to REIC/Dkk-3-induced apoptosis in human bladder cancer cells.2008
Author(s)
Kobayashi T, Sakaguchi M, Tanimoto R, Abarzua F, Takaishi M, Kaku H, Kataoka K, Saika T, Nasu Y, Miyazaki M, Kumon H, Huh NH.
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Journal Title
Acta Med Okayama. 62(6)
Pages: 393-401
Peer Reviewed
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[Journal Article] An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis.2008
Author(s)
Abarzua F, Kashiwakura Y, Takaoka M, Watanabe M, Ochiai K, Sakaguchi M, Iwawaki T, Tanimoto R, Nasu Y, Huh NH, Kumon H.
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Journal Title
Biochem Biophys Res Commun. 375(4)
Pages: 614-618
Peer Reviewed
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