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2010 Fiscal Year Final Research Report

Targeted drug delivery to tumor endothelial surface.

Research Project

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Project/Area Number 20390433
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SUGIHARA Kazuhiro  Hamamatsu University School of Medicine, 医学部, 准教授 (00265878)

Co-Investigator(Kenkyū-buntansha) KANAYAMA Naohiro  浜松医科大学, 医学部, 教授 (70204550)
ITOH Hiroaki  浜松医科大学, 医学部附属病院, 准教授 (70263085)
MAGATA Yasuhiro  浜松医科大学, 光量子医学研究センター, 教授 (20209399)
KOUMURA Yasuhiro  浜松医科大学, 医学部附属病院, 助教 (50332995)
Project Period (FY) 2008 – 2010
Keywords婦人科腫瘍学 / 分子標的治療薬
Research Abstract

Among previously identified carbohydrate-mimicry peptides, we found one peptide (Proc Natl Acad Sci USA. 2009), designated as IF7, binds to Annexin 1 (Anxa1), a highly specific tumor endothelial cell surface marker. A synthetic IF7 peptide conjugated with fluorescent Alexa 488 targeted the tumor within several minutes of intravenous injection, which was inhibited by anti-Anxa1 antibody. IF7 conjugated with the anti-cancer drug was injected intravenously into nude mice carrying luciferase-positive tumors produced by human cancer cells. IVIS[○!R] Living 3D Image System showed that IF7-anticancer drug treatment substantially suppressed tumor growth, while in some cases the tumor disappeared. IF7-anticancer drug was effective at low dosages, and mice showed no apparent side effects following drug treatment. Given its extremely specific tumor-targeting activity, IF7 therefore represent a clinically relevant vehicle for anticancer drugs.

  • Research Products

    (20 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells.2009

    • Author(s)
      Hatakeyama S, Sugihara K, Nakayama J, Akama T, Wong S-M, Kawashima H, Zhang J, Smith D, Ohyarna C, Fukuda M, Fukuda NM
    • Journal Title

      Proc Natl Acad Sci USA.3 106(9)

      Pages: 3095-3100

    • Peer Reviewed
  • [Journal Article] Antitumor effect of photodynamic therapy in mice using direct application of Photofrin dissolved in lidocaine jelly2009

    • Author(s)
      Murakami H, Kohno E, Kohmura Y, Ozawa H, Itoh H, SuQihara K, Horiuchi K, Hirano T, Kanavama N
    • Journal Title

      Photodermatol Photoimmunol Photomed. 25(5)

      Pages: 259-263

    • Peer Reviewed
  • [Journal Article] A rare form of extraovarian peritoneal serous papillary carcinoma with solitary tumor in the abdominal wall : a case report and literature review.2009

    • Author(s)
      Matsuura T, Sugihara K, Kohmura Y, Sugimura H, Kanavama N
    • Journal Title

      J Obstet Gynaecol Res. 35(6)

      Pages: 1142-1147

    • Peer Reviewed
  • [Journal Article] Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro.2009

    • Author(s)
      Tanaka A, Suzuki Y, SuQihara K, Kanavama N, Urano T
    • Journal Title

      Life Sci.1 85(5-6)

      Pages: 220-225

    • Peer Reviewed
  • [Journal Article] Chorangiosis and placental oxygenation.2009

    • Author(s)
      Suzuki K, Itch H, Kimura S, SuQihara K, Yaguchi C, Kobayashi Y, Hirai K, Takeuchi K, Sugimura M, Kanavama N
    • Journal Title

      Congenit Anom. 49(2)

      Pages: 71-76

    • Peer Reviewed
  • [Presentation] 糖鎖をmimicするペプチドIF7を用いた新規DDS型悪性腫瘍治療薬2010

    • Author(s)
      杉原一廣
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100922-20100924
  • [Presentation] 糖鎖をmimicするペプチドを用いた新規DDS型悪性腫瘍治療薬の開発ワークショップ:蛋白質および糖鎖解析によるバイオマーカー探索2010

    • Author(s)
      杉原一廣
    • Organizer
      第20回日本サイトメトリー学会学術集会東京
    • Place of Presentation
      東京
    • Year and Date
      20100626-20100627
  • [Presentation] 癌治療への新しい取り組み2010

    • Author(s)
      杉原一廣
    • Organizer
      第8回静岡がん治療フォーラム
    • Place of Presentation
      浜松
    • Year and Date
      2010-10-08
  • [Presentation] 糖鎖をmimicするペプチドを用いた新規DDS型悪性腫瘍治療薬の開発2010

    • Author(s)
      杉原一廣
    • Organizer
      第9回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      大津
    • Year and Date
      2010-09-10
  • [Presentation] 「新たな治療を求めて」教育セミナー:糖鎖をmimicするペプチドをtargeting-vehicleとした新規分子標的治療薬2009

    • Author(s)
      杉原一廣
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20091022-20091024
  • [Presentation] 糖鎖と糖鎖をリガンドとする受容体を標的とする癌治療薬の開発2009

    • Author(s)
      杉原一廣
    • Organizer
      Recent Advance in Tumor Angiogenesis 2009
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-31
  • [Presentation] 分子をmimicするペプチドを用いた研究2009

    • Author(s)
      杉原一廣
    • Organizer
      第27回周産期医療研究会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-02
  • [Presentation] 基礎研究から創薬へ2009

    • Author(s)
      杉原一廣
    • Organizer
      平成21年キッセイ薬品工業中央研究所講演会
    • Place of Presentation
      長野
    • Year and Date
      2009-08-20
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的研究2009

    • Author(s)
      杉原一廣
    • Organizer
      第8回日本婦人科がん分子標的研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-03
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20081030-20081101
  • [Presentation] 糖鎖をmimicするペプチドを用い腫瘍血管内皮を標的とする分子標的治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第44回日本婦人科腫瘍学会学術集会・第7回日本婦人科がん分子標的研究会
    • Place of Presentation
      名古屋
    • Year and Date
      20080717-20080719
  • [Presentation] Targeted apoptosis of tumor vasculature by carbohydrate-mimicy peptide.2008

    • Author(s)
      Hatakeyama S, Sugihara K, et al.
    • Organizer
      The 6th International Glyco T 2008 meeting in Atlanta.
    • Place of Presentation
      Georgia, USA.
    • Year and Date
      20080517-20080520
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的癌治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第60回日本産科婦人科学会・総会・学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      20080400
  • [Remarks] ホームページ

    • URL

      http://www.hama-med.ac.jp/uni_introduction_report_souran_07161504.hhnl

  • [Patent(Industrial Property Rights)] 「METHODS AND COMPOSITIONS RELATED TO ANNEXIN 1-BINDING COMPOUNDS」(腫瘍新生血管内皮を標的とする新規抗癌剤)2009

    • Inventor(s)
      杉原一廣, 他
    • Industrial Property Rights Holder
      杉原一廣, 他
    • Industrial Property Number
      特許,No.61/289,833
    • Filing Date
      2009-12-23

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Published: 2012-01-26   Modified: 2016-04-21  

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