2010 Fiscal Year Final Research Report
Targeted drug delivery to tumor endothelial surface.
| Project/Area Number |
20390433
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SUGIHARA Kazuhiro Hamamatsu University School of Medicine, 医学部, 准教授 (00265878)
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Naohiro 浜松医科大学, 医学部, 教授 (70204550)
ITOH Hiroaki 浜松医科大学, 医学部附属病院, 准教授 (70263085)
MAGATA Yasuhiro 浜松医科大学, 光量子医学研究センター, 教授 (20209399)
KOUMURA Yasuhiro 浜松医科大学, 医学部附属病院, 助教 (50332995)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 婦人科腫瘍学 / 分子標的治療薬 |
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| Research Abstract |
Among previously identified carbohydrate-mimicry peptides, we found one peptide (Proc Natl Acad Sci USA. 2009), designated as IF7, binds to Annexin 1 (Anxa1), a highly specific tumor endothelial cell surface marker. A synthetic IF7 peptide conjugated with fluorescent Alexa 488 targeted the tumor within several minutes of intravenous injection, which was inhibited by anti-Anxa1 antibody. IF7 conjugated with the anti-cancer drug was injected intravenously into nude mice carrying luciferase-positive tumors produced by human cancer cells. IVIS[○!R] Living 3D Image System showed that IF7-anticancer drug treatment substantially suppressed tumor growth, while in some cases the tumor disappeared. IF7-anticancer drug was effective at low dosages, and mice showed no apparent side effects following drug treatment. Given its extremely specific tumor-targeting activity, IF7 therefore represent a clinically relevant vehicle for anticancer drugs.
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[Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells.2009
Author(s)
Hatakeyama S, Sugihara K, Nakayama J, Akama T, Wong S-M, Kawashima H, Zhang J, Smith D, Ohyarna C, Fukuda M, Fukuda NM
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Journal Title
Proc Natl Acad Sci USA.3 106(9)
Pages: 3095-3100
Peer Reviewed
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