2010 Fiscal Year Final Research Report
Development of a novel animal model of endometriosis using magnetic materials
| Project/Area Number |
20390436
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
MARUYAMA Tetsuo Keio University, 医学部, 講師 (10209702)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Hiroshi 慶應義塾大学, 医学部, 助教 (90286534)
KAJITANI Takashi 帝京大学, 医学部, 助教 (60407111)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 子宮内膜症 / 応用動物 / 幹細胞 / 血管新生 |
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| Research Abstract |
The aim of this research project was to develop a novel animal model of endometriosis using magnetic materials which enables non-invasive and real-time of assessment of the endometriotic lesion by in vivo imaging. We first have developed a lentivirus vector enabling the expression of a non-functional surface marker and fluorescent and luminescent proteins in infected cells. We then successfully isolated the infected endometrial cells and accumulated them to the specific site in vivo using magnetic materials. Finally, we were able to assess the behavior of the reconstructed lesion in non-invasive and real-time manner using in vivo imaging system.
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[Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration.2010
Author(s)
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
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Journal Title
PLoS ONE. 5(4)
Pages: e10387
Peer Reviewed
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[Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.2009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, TamakiK, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
J Immunol. 182(11)
Pages: 7074-7084
Peer Reviewed
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[Journal Article] Activation of SRC kinase and phosphorylation of STAT5 are required for decidual transformation of human endometrial stromal cells.2008
Author(s)
Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
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Journal Title
Endocrinology. 149(3)
Pages: 1227-1234
Peer Reviewed
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[Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis.2010
Author(s)
Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida, Hironori Asada, Yasunori Yoshimura
Organizer
The First Asian Conference on Endometriosis(ACE).
Place of Presentation
Shanghai, China(招請講演)
Year and Date
20101016-20101017
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