2010 Fiscal Year Final Research Report
The development of a new therapeutic moleculefor Japanese cedar pollinosis by proteomics analysis in the serum of patients treated with sublingual immunotherapy
| Project/Area Number |
20390441
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
FUJIEDA Shigeharu University of Fukui, 医学部, 教授 (30238539)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Emiko 筑波大学, 人間総合科学研究科, 准教授 (40344882)
YAMADA Takechiyo 福井大学, 医学部附属病院, 講師 (70283182)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 鼻科学 / アレルギー学 / スギ花粉症 / 舌下免疫療法 / 網羅的蛋白解析 / アポ蛋白A-4 / DAF / Filaggrin |
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| Research Abstract |
Seasonal allergic rhinitis caused by Japanese cedar (SAR-JC) is the most common allergic disease in Japan. The results of our recent study showed that about 30% of Japanese individuals develop allergic symptoms during JC pollination season. Allergen-specific immunotherapy (SIT) is the only available treatment that can provide long-term remission after discontinuation of treatment. Sublingual immunotherapy (SLIT), oral administration of the allergen, was introduced as a safety method. We found that apolipoprotein A-IV (apoA-IV) were significantly increased in SLIT-treated patients. The serum levels of apoA-IV correlated with the clinical effect. The amount of histamine released from the basophils in vitro was greatly reduced after the addition of recombinant apoA-IV in the medium. Our genetic studies found the association of polymorphisms of IL-33, DAF and Filaggrin with SAR-JC. They are possible therapeutic targets for SAR-JC.
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