2010 Fiscal Year Final Research Report
Differences of susceptibility and aging of inner damage
| Project/Area Number |
20390444
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
OGAWA Kaoru Keio University, 医学部 (00169179)
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| Co-Investigator(Kenkyū-buntansha) |
TSUDA Reo 国立長寿センター, 老化機構研究部, 室長 (30333355)
KANZAKI Sho 慶應義塾大学, 医学部, 講師 (50286556)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 易受傷性 / 内耳障害 / 有毛細胞 / 活性酸素 / オートファジー |
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| Research Abstract |
We concluded that differences of free radical scavenger and autophagy between individuals can determine inner ear homeostasis. OGG (free radical scavenger gene) KO mice exposed to acoustic trauma demonstrated more hair cells damages compared to wild type mice as control. Autophagy 7 conditional knockout mice presented stereocilia loss. It may suggest that autophagy is critical factor for maintaining hair cells. One study is still ongoing research regarding functional and morphological analysis of TBL-1 KO mice which we proposed as presbycusis mice model
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