2010 Fiscal Year Final Research Report
Development of new treatment modality for diabetic macular edema using knockout mice that show prominent retinal edema.
| Project/Area Number |
20390447
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINDO Takayuki 信州大学, 医学系研究科, 教授 (90345215)
ISHIBASHI Tatsuro 九州大学, 医学系研究科, 教授 (30150428)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 眼細胞生物学糖尿病黄斑浮腫治療 |
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| Research Abstract |
Homozygote RAMP-2 knockout(KO) mice are fatal before delivery, but heterozygote RAMP-2 KO mice show largely normal development except for systemic edema. We found these mice have marked retinal edema. Diabetic retinal edema is a leading cause of legal blindness. There has been no animal model for retinal edema.(RAMP)-2 knockout mice are new and the only existing animal model of retinal edema. Using this model, we reported that insufficient formation of tight junction and disruption of Bruch' s membrane are potential causes of breakdown of blood-retinal barrier.
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Research Products
(9 results)
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[Journal Article] Stable Retinal Gene Expression in Nonhuman Primates via Subretinal Injection of SIVagm-based Lentiviral Vectors2009
Author(s)
Ikeda Y, Murata T, Tabata T, Ueda Y, Ono F, Suzuki T, Ageyama N, Terao K, Hasegawa M, Sueishi K, Ishibashi T
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Journal Title
Hum Gene Ther
Volume: 20(6)
Pages: 573-579
Peer Reviewed
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