2010 Fiscal Year Final Research Report
Elucidating the molecular pathology and development of treatment modalities for ischemic retinopathies
| Project/Area Number |
20390448
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
TERASAKI Hiroko Nagoya University, 大学院・医学系研究科, 教授 (40207478)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Mineo 名古屋大学, 大学院・医学系研究科, 准教授 (80303642)
ITO Yasuki 名古屋大学, 大学院・医学系研究科, 准教授 (10313991)
KACHI Shu 名古屋大学, 医学部附属病院, 講師 (30345904)
NISHIGUCHI Koji 名古屋大学, 医学部附属病院, 助教 (30447825)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 未熟児網膜症 / 光干渉断層計 / 加齢黄斑変性症 / 血管内皮増殖因子 / ヘパリン / 脈絡膜 / 脈絡膜新生血管 / 網膜静脈分枝閉塞症 |
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| Research Abstract |
The intraocular dynamics of VEGF plays a critical role in the pathogenesis of ischemic retinopathy including branch retinal vein occlusion. The long term suppression of intraocular VEGF levels proved important to maintain vision. In the experiments using mice, the role of inflammatory cells in the peripheral circulation was shown not to be essential for the formation of retinal neovascularization. Meanwhile, macrophages in the vitreous may be important in this aspect.
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