Study of vitreous body : Analysis of microenvironmental control and development of novel treatment.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390450
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kagoshima University
• Principal Investigator: SAKAMOTO Taiji Kagoshima University, 医歯学総合研究科, 教授 (10235179)
• Project Period (FY): 2008 – 2011
• Keywords: SDF-1 / 硝子体免疫 / 薬物治療 / 超音波

Research Abstract

硝子体は単なる透明な結合組織ではなく、眼内の環境維持に重要な働きをすることを、硝子体内のサイトカインのみでなく、蛋白分解産物(デグラドーム)を解析することで解明する。そのことで硝子体内の環境維持の新たな局面を解明し「硝子体学」を確立するための基礎データを収集することが本研究の目的である。硝子体細胞

Research Products

• [Journal Article] Ocular surface molecule after transconjunctival vitrectomy (2011)
  • Author(s): Fujita A, Uchino E, Otsuka H, Arimura N, Noda N, Ishibashi T, Sakamoto T.
  • Journal Title: Br J Ophthalmol. 95(3) Pages: 419-423
• [Journal Article] Incidence of outer foveal defect after macular hole surgery. (2011)
  • Author(s): Kawano H, Uemura A, Sakamoto T.
  • Journal Title: Am J Ophthalmol. 151(2) Pages: 318-322
• [Journal Article] Hyalocytes : Essential cells of the vitreous cavity in vitreoretinal pathophysiology? (2011)
  • Author(s): Sakamoto T. Ishibashi T.
  • Journal Title: Retina 31(2) Pages: 222-228
• [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment. (2010)
  • Author(s): Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T.
  • Journal Title: Am J Pathol. 177(5) Pages: 2268-2277
• [Journal Article] Combination therapy for retinal vein occlusion (2010)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Takeshita T, Shiono T, Sakamoto T
  • Journal Title: Ophthalmology 117(9) Pages: 1858, 1858.e1-3.
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. (2009)
  • Author(s): Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I
  • Journal Title: Lab Invest. 89(3) Pages: 278-289
• [Journal Article] Posturing time after macular hole surgery modified by optical coherence tomography images : a pilot study. (2009)
  • Author(s): Masuyama K, Yamakiri K, Arimura N, Sonoda Y, Doi N, Sakamoto T.
  • Journal Title: Am J Ophthalmol. 147(3) Pages: 481-488
• [Presentation] Intravitreous mediators in diabetic retinopathy. (2010)
  • Author(s): Sakamoto T.
  • Organizer: Sympsium. ARVO summer conference
  • Place of Presentation: NIH, Bethesda, USA
  • Year and Date: 20100801-20100802
• [Presentation] Chromovitrectomy.Rebert Burns lecture of Mason Eye Institute (Part 2) (2010)
  • Author(s): Sakamoto T
  • Organizer: University of Missouri
  • Place of Presentation: Colombia, Missouri, USA
  • Year and Date: 2010-10-23
• [Presentation] CD9 as a therapeutic target of ocular diseases (invited speaker symposium) (2009)
  • Author(s): Sakamoto T, Kamisasanuki T, Kosai S
  • Organizer: 8th International symposium of ocular pharmacology and therapeutics.
  • Place of Presentation: Rome Cavaliori, Rome, Italy
  • Year and Date: 2009-12-04
• [Presentation] Immediate change after intravitreous triamcinolone for diabetic macular edema. Invited lecture.Symposium of macular disorder. (2009)
  • Author(s): Sakamoto T.
  • Organizer: 4th Asia-Pacific Vitreo-Retinal Society, The Grand Hotel
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-11-11
• [Presentation] Intravitreous staining by triamcinolone during PPV. (2009)
  • Author(s): Sakamoto T.
  • Organizer: Symposium.107th Deutche Ophthalmol.Gesellshaft
  • Place of Presentation: Leipzig Messe, Leipzig, Germany.
  • Year and Date: 2009-09-26
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2010)
  • Inventor(s): 小戝健一郎、坂本泰二、上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: PCT/JP2010/0577735
  • Filing Date: 2010-04-19
  • Overseas
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2009)
  • Inventor(s): 小戝健一郎、坂本泰二、上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: 2009-105170
  • Filing Date: 2009-04-23