• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.

Research Project

  • PDF
Project/Area Number 20390453
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

IWAI Naomi  Kyoto Prefectural University of Medicine, 医学研究科, 教授 (90128695)

Co-Investigator(Kenkyū-buntansha) KIMURA Osamu  京都府立医科大学, 医学研究科, 准教授 (10315963)
SASAKI Yasunari  京都府立医科大学, 医学研究科, 助教 (30405253)
Project Period (FY) 2008 – 2010
Keywords先天性消化器疾患学
Research Abstract

In the embryos affected by all trans retinoic acid (ATRA) only, all of them had anorectalmalformations (ARM). In the embryos affected by ATRA and LE135, however, about 40% of the embryos had normal rectum and anus but had short tail. Therefore, these findings indicate that RA receptor antagonist prevents disturbance of the cell signaling pathway between the epithelium and the mesenchyme layers because RA receptor antagonist inhibits RA receptor from forming heterodimers with RX receptors.

  • Research Products

    (10 results)

All 2010 2009 2008 Other

All Journal Article (6 results) Presentation (3 results) Book (1 results)

  • [Journal Article] 直腸肛門内圧検査佐々木康成2010

    • Author(s)
      岩井直躬、木村修、小野滋、津田知樹
    • Journal Title

      小児外科 42(7)

      Pages: 756-759

  • [Journal Article] 直腸肛門奇形術後の長期フォローアップ-20歳以上-2010

    • Author(s)
      岩井直躬、佐々木康成、出口英一、岩田譲司、木村修、久保田良浩、深田良一、小野滋
    • Journal Title

      周産期医学 40(8)

      Pages: 1245-1249

  • [Journal Article] 腹会陰式直腸肛門形成術術後成人例におけるQOL2010

    • Author(s)
      津田知樹、岩井直躬、木村修、小野滋、古川泰三、佐々木康成、出口英一、久保田良浩
    • Journal Title

      小児外科 42(11)

      Pages: 1201-1204

  • [Journal Article] Congenital anomalies induced by triamcinolone acetonide in murine embryos.2008

    • Author(s)
      Miyagi Y, Kubota Y, Tsuda T, Sasaki Y, Ono S, Kimura O, Iwai N.
    • Journal Title

      Eur J Pediatr Surg 18(3)

      Pages: 164-167

  • [Journal Article] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.

    • Author(s)
      佐々木康成, 岩井直躬, 木村修, 小野滋, 津田知樹
    • Journal Title

      J Pediatr Surg in press

  • [Journal Article] PCSK5 and GDF11 Expression in the Hindgut Region of Mouse Embryos with Anorectal Malformations.

    • Author(s)
      Tsuda T, Iwai N, Deguchi E, Kimura O, Ono S, Furukawa T, Sasaki Y, Fumino S, Kubota Y.
    • Journal Title

      Eur J Pediatr Surg in press

  • [Presentation] Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.2010

    • Author(s)
      Sasaki Y, Iwai N, Kimura O, Ono S, Tsuda T, Tanaka T.
    • Organizer
      British Association of Pediatric Surgeons 57th Annual International
    • Place of Presentation
      Congress Aberdeen UK
    • Year and Date
      20100720-20100724
  • [Presentation] PCSK5 and GDF expression in the hindgut region of mouse embryo with anorectal malformations.2010

    • Author(s)
      Tsuda T, Iwai N, Kimura O, Ono S, Sasaki Y, Fumino S
    • Organizer
      British Association of Pediatric Surgeons 57th Annual International
    • Place of Presentation
      Congress Aberdeen UK
    • Year and Date
      20100720-20100724
  • [Presentation] Laparoscopic vs. open Abdomino perineal anorectoplasty for infants with the high type of anorectal malformation.2010

    • Author(s)
      Kimura O, Iwai N, Sasaki Y, Tsuda T, Deguchi E, Ono S, Furukawa T, Fumino S
    • Organizer
      43^<rd> Annual Meeting of Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20100000
  • [Book] 消化管症候群(下)日本臨床2009

    • Author(s)
      岩井直躬、佐々木康成、小野滋

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi