2010 Fiscal Year Final Research Report
Establishment of a rescue program for anorectal malformations induced by retinoic acid in mice.
| Project/Area Number |
20390453
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IWAI Naomi Kyoto Prefectural University of Medicine, 医学研究科, 教授 (90128695)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Osamu 京都府立医科大学, 医学研究科, 准教授 (10315963)
SASAKI Yasunari 京都府立医科大学, 医学研究科, 助教 (30405253)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 先天性消化器疾患学 |
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| Research Abstract |
In the embryos affected by all trans retinoic acid (ATRA) only, all of them had anorectalmalformations (ARM). In the embryos affected by ATRA and LE135, however, about 40% of the embryos had normal rectum and anus but had short tail. Therefore, these findings indicate that RA receptor antagonist prevents disturbance of the cell signaling pathway between the epithelium and the mesenchyme layers because RA receptor antagonist inhibits RA receptor from forming heterodimers with RX receptors.
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