Demonstration of PACAP on protection of delayed neuronal cell death and its molecular mechanism of neuroregeneration.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390461
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Showa University
• Principal Investigator: SHIODA Seiji Showa University, 医学部, 教授 (80102375)
• Co-Investigator(Kenkyū-buntansha): OHTAKI Hirokazu 昭和大学, 医学部, 助教 (20349062) ; NAKANACHI Tomoya 昭和大学, 遺伝子組換え実験室, 助教 (30433840)
• Co-Investigator(Renkei-kenkyūsha): ARATA Satoru 昭和大学, 遺伝子組換え実験室, 准教授 (20159502)
• Project Period (FY): 2008 – 2010
• Keywords: PACAP / PAC1-R / IL-6 / 神経細胞死 / 神経再生

Research Abstract

We have studied to clarify the molecular basis for PACAP on protection of delayed neuronal cell death after brain ischemia in mice and to make a translational study for humans. I n addition, we have also studied the molecular mechanism of PACAP on stimulating differentiation from neural stem cells into neurons and/or glial cells. Moreover, we developed a new drug delivery system (DDS) of PACAP by use of intranasal infusion to protect delayed neuronal cell death after brain ischemia. The present study will have a strong impact for protection of brain ischemia and it will open a new avenue to use of PACAP and its related peptides for clinical use for patients who will be suffered from neurodegeneration after brain ischemia with a new developed DDS.

Research Products

• [Journal Article] Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits. (2011)
  • Author(s): Tanaka S, Kondo H, Kanda K, Ashino T, Nakamachi T, Sekikawa K, Iwakura Y, Shioda S, Numazawa S, Yoshida T
  • Journal Title: J Neurosci Res 89(4) Pages: 506-14
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse. (2011)
  • Author(s): Endo K, Nakamachi T, Seki T, Kagami N, Wada Y, Nakamura K, Kishimoto K, Hori M, Tsuchikawa D, Shinntani N, Hashimoto H, Baba A, Koide R, Shioda S
  • Journal Title: J Mol Neurosci 43(1) Pages: 22-9
  • Peer Reviewed
• [Journal Article] Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. (2010)
  • Author(s): Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
  • Journal Title: J Neuroinflammation 7 Pages: 41
  • Peer Reviewed
• [Journal Article] Regulation of Oxidative Stress by Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Mediated by PACAP Receptor. (2010)
  • Author(s): Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S
  • Journal Title: J Mol Neurosci 42(3) Pages: 397-403
  • Peer Reviewed
• [Journal Article] Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice. (2010)
  • Author(s): Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, hintani N, Hashimoto H, Baba A, Shioda S
  • Journal Title: Circ J 74(6) Pages: 1183-1190
  • Peer Reviewed
• [Journal Article] Nucleoprotein Diet Ameliorates Arthritis Symptoms in Mice Transgenic for Human T-Cell Leukemia Virus Type I (HTLV-1). (2010)
  • Author(s): Ohtaki H, Yofu S, Nakamachi T, Satoh K, Shimizu A, Mori H, Sato A, Iwakura Y, Matsunaga M, Shioda S
  • Journal Title: J Clin Biochem Nutr 46(2) Pages: 93-104
  • Peer Reviewed
• [Journal Article] Glial fibrillary acidic protein-expressing neural progenitors give rise to immature neurons via early intermediate progenitors expressing both glial fibrillary acidic protein and neuronal markers in the adult hippocampus. (2010)
  • Author(s): Liu Y, Namba T, Liu J, Suzuki R, Shioda S, Seki T
  • Journal Title: Neuroscience 166(1) Pages: 241-251
  • Peer Reviewed
• [Journal Article] Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain. (2010)
  • Author(s): Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N, Baba A, Shioda S
  • Journal Title: Acta Neurochir Suppl 106 Pages: 43-46
  • Peer Reviewed
• [Journal Article] Novel free radical monitoring in patients with neurological emergency diseases. (2010)
  • Author(s): Dohi K, Satoh K, Nakamachi T, Ohtaki H, Yofu S, Nakamura S, Shioda S, Aruga T
  • Journal Title: Acta Neurochir Suppl 106 Pages: 315-319
  • Peer Reviewed
• [Journal Article] Activation of microglia induced learning and memory deficits. (2009)
  • Author(s): Tanaka S, Ohtaki H, Nakamachi T, Shioda S, 他2名
  • Journal Title: Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience-(Springer (Tokyo)) Pages: 191-197
  • Peer Reviewed
• [Journal Article] Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice. (2009)
  • Author(s): Morikawa K, Dohi K, Nakamachi T, Ohtaki H, Shioda S, 他3名
  • Journal Title: Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience-(Springer (Tokyo)) Pages: 207-210
  • Peer Reviewed
• [Journal Article] Isolation of Peptide transport system-6 from brain endothelial cells : thrapeutic effects with antisense inhibition in Alzheimer and stroke models. (2009)
  • Author(s): Dogrukol-Ak D, Nonaka N, Nakamachi T, Ohtaki H, Shioda S, Banks WA, 他7名
  • Journal Title: J Cereb Blood Flow Metab 29(2) Pages: 411-422
  • Peer Reviewed
• [Journal Article] Activation of microglia induced learning and memory deficits. (2009)
  • Author(s): Tanaka S, Ohtaki H, Nakamachi T, Numazawa S, Shioda S, Yoshida T
  • Journal Title: Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience-(Springer (Tokyo)) Pages: 191-197
  • Peer Reviewed
• [Journal Article] Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1) transgenic mice. (2009)
  • Author(s): Arata S, Hosono T, Taketomi Y, Kageyama H, Nakamachi T, Shioda S
  • Journal Title: Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience-(Springer (Tokyo)) Pages: 199-205
  • Peer Reviewed
• [Journal Article] Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice. (2009)
  • Author(s): Morikawa K, Dohi K, Yofu S, Mihara Y, Nakamachi T, Ohtaki H, Shioda S, Aruga T
  • Journal Title: Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience(Springer (Tokyo)) Pages: 207-210
  • Peer Reviewed
• [Journal Article] Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity. (2009)
  • Author(s): Watanabe J, Nakamachi T, Ogawa T, Naganuma A, Nakamura M, Shioda S, Nakajo S
  • Journal Title: J Toxicol Sci 34(3) Pages: 315-325
  • Peer Reviewed
• [Journal Article] Biphasic effects of neonatal allopregnanolone on striatal dopamine metabolism. (2009)
  • Author(s): Muneoka K, Kuwagata M, Shirayama Y, Ogawa T, Shioda S
  • Journal Title: Neuroreport 20(9) Pages: 860-863
  • Peer Reviewed
• [Journal Article] Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. (2009)
  • Author(s): Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J
  • Journal Title: Dev Biol 327(1) Pages: 106-120
  • Peer Reviewed
• [Journal Article] Isolation of peptide transport system-6 from brain endothelial cells : therapeutic effects with antisense inhibition in Alzheimer and stroke models. (2009)
  • Author(s): Dogrukol-Ak D, Kumar VB, Ryerse JS, Farr SA, Verma S, Nonaka N, Nakamachi T, Ohtaki H, Niehoff ML, Edwards JC, Shioda S, Morley JE, Banks WA
  • Journal Title: J Cereb Blood Flow Metab 29(2) Pages: 411-422
  • Peer Reviewed
• [Journal Article] Brain region-specific effects of short-term treatment with duloxetine, venlafaxine, milnacipran and sertraline on monoamine metabolism in rats. (2009)
  • Author(s): Muneoka K, Shirayama Y, Takigawa M, Shioda S
  • Journal Title: Neurochem Res 34(3) Pages: 542-455
  • Peer Reviewed
• [Journal Article] Role of PACAP in ischemic neural death. (2008)
  • Author(s): Ohtaki H, Nakamachi T, Dohi K, Shioda S
  • Journal Title: J Mol Neurosci 36(1-3) Pages: 16-25
  • Peer Reviewed
• [Journal Article] Negative feedback regulation of lipopolysaccharide-induced nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. (2008)
  • Author(s): Ashino T, Yamanaka R, Shioda S, Numazawa S, Yoshida T, 他4名
  • Journal Title: Mol Immunol 45(7) Pages: 2106-2115
  • Peer Reviewed
• [Journal Article] Delivery of galanin-like peptide to the brain : targeting with intranasal delivery and cyclodextrins. (2008)
  • Author(s): Nonaka N, Farr SA, Kageyama H, Shioda S, Banks WA
  • Journal Title: J Pharmacol Exp Ther 325(2) Pages: 513-519
  • Peer Reviewed
• [Journal Article] The presence and distribution of pituitary adenylate cyclase activating polypeptide and its receptor in the snail Helix pomatia. (2008)
  • Author(s): Hernadi L, Pirger T, Shioda S, Reglodi D, 他6名
  • Journal Title: Neuroscience 155(2) Pages: 387-402
  • Peer Reviewed
• [Journal Article] Suppression of ganglion cell death by PACAP following optic nerve transection in the rat. (2008)
  • Author(s): Seki T, Itoh H, Nakamachi T, Shioda S
  • Journal Title: J Mol Neurosci 36(1-3) Pages: 57-60
  • Peer Reviewed
• [Journal Article] Changes in the expression of PACAP-like compounds during the embryonic development of the earthworm Eisenia fetida. (2008)
  • Author(s): Boros A, Reglodi D, Shioda S, Matsuda K, Molnar L, 他7名
  • Journal Title: J Mol Neurosci 36(1-3) Pages: 157-165
  • Peer Reviewed
• [Journal Article] Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. (2008)
  • Author(s): Ohtaki H, Ylostalo JH, Foraker JE, Shioda S, Prockop DJ, 他2名
  • Journal Title: Proc Natl Acad Sci USA 105(38) Pages: 14638-14643
  • Peer Reviewed
• [Journal Article] Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1) transgenic mice.
  • Author(s): Arata S, Hosono T, Kageyama H, Nakamachi T, Shioda S, 他1名
  • Journal Title: Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience-(Springer (Tokyo)) Pages: 2009199-205
  • Peer Reviewed
• [Journal Article] Expression and Localization of the Orexin-1 Receptor (OX1R) After Traumatic Brain Injury in Mice.
  • Author(s): Mihara Y, Dohi K, Yofu S, Nakamachi T, Ohtaki H, Shioda S, Aruga T
  • Journal Title: J Mol Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Distribution of the longevity gene product, SIRT1, in developing mouse organs.
  • Author(s): Ogawa T, Wakai C, Saito T, Murayama A, Mimura Y, Youfu S, Nakamachi T, Kuwagata M, Satoh K, Shioda S
  • Journal Title: Congenit Anom (Kyoto) (in press)
  • Peer Reviewed
• [Journal Article] Suppression of Rat Retinal Ganglion Cell Death by PACAP Following Transient Ischemia Induced by High Intraocular Pressure.
  • Author(s): Seki T, Itoh H, Nakamachi T, Endo K, Wada Y, Nakamura K, Shioda S
  • Journal Title: J Mol Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Stimulates Proliferation of Reactive Astrocytes In Vitro.
  • Author(s): Nakamachi T, Nakamura K, Oshida K, Kagami N, Mori H, Watanabe J, Arata S, Yofu S, Endo K, Wada Y, Hori M, Tsuchikawa D, Kato M, Shioda S
  • Journal Title: J Mol Neurosci (in press)
  • Peer Reviewed
• [Presentation] PACAP遺伝子欠損マウスにおける呼吸機能異常 (2011)
  • Author(s): 中町智哉、荒田悟、鬼丸洋、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜(シンポジスト)
  • Year and Date: 20110300
• [Presentation] 核蛋白質によるパーキンソン病予防効果の検討 (2011)
  • Author(s): 小林夏季、大滝博和、宋丹丹、宮本和幸、圓谷智海、吉田武美、松永政司、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110300
• [Presentation] 内因性PACAPはマウスにおけるNMDA誘発性網膜障害に対して神経保護因子として機能する (2011)
  • Author(s): 和田悦洋、遠藤貴美、中町智哉、関保、加賀美信幸、中村圭輔、堀元英、土川大介、新谷紀人、橋本均、馬場明道、小出良平、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110300
• [Presentation] 若齢および高齢マウス唾液腺におけるPACAPとPAC-1レセプター局在の検討 (2011)
  • Author(s): 野中直子・中町智哉・塩田清二・中村雅典
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110300
• [Presentation] 異なる継代回数における骨髄由来間葉系幹細胞の特性比較 (2011)
  • Author(s): 宋丹丹、大滝博和、小林夏季、圓谷智海、平泉裕、井上富雄、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110300
• [Presentation] 脳虚血におけるPACAPの神経保護作用:遺伝子とタンパク質の発現から見た分子的要素の解析 (2011)
  • Author(s): 堀元英・Randeep Rakwal・柴藤淳子・中町智哉・玉木敬二・塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110300
• [Presentation] Effects of pituitary adenylate cyclase activating polypeptide (PACAP) in corneal epithelial regeneration andsignal transduction in rats. (2011)
  • Author(s): Shioda S, J Farkas, L Mester, K Kovacs, D Reglodi, A Matkovits, V Gaal, Z Biro, A Szabo, B Racz, K Szabadfi, A Lubics, T Atlasz, A Tamas, T Nakamachi, P Kiss
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110300
• [Presentation] PACAP and neuronal cell death. (2010)
  • Author(s): 塩田清二
  • Organizer: 5th International Peptide Symposium
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20101200
• [Presentation] Retinal Protective Effect of Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Against NMDA-induced Damage in Mice. (2010)
  • Author(s): Nakamachi T, Endo K, Seki T, Kagami N, Nakamura K, Wada Y, Kishimoto K, Farkas J, Arata S, Shioda S
  • Organizer: 5th International Peptide Symposium
  • Place of Presentation: Kyoto
  • Year and Date: 20101200
• [Presentation] Effect of pituitary adenylate cyclase activating polypeptide (PACAP) in corneal epithelial regeneration and signal transduction in rats. (2010)
  • Author(s): Farkas J, Mester L, Kovacs K, Reglodi D, Matkovits A, Gaal V, Biro Z, Szabo A, Racz B Szabadfi K, Lubics A, Tamas A, Atlasz T, Shioda S, Nakamachi T, Kiss P
  • Organizer: 5th International Peptide Symposium
  • Place of Presentation: Kyoto
  • Year and Date: 20101200
• [Presentation] マウスにおけるPACAPの涙液分泌促進効果 (2010)
  • Author(s): 中町智哉
  • Organizer: 第35回日本比較内分泌学会大会
  • Place of Presentation: 静岡
  • Year and Date: 20101100
• [Presentation] Human MSCs suppress neuronal cell death after ischemia by anti-inflammation. (2010)
  • Author(s): Ohtaki H, Ylostalo J, Song D, Kobayashi N, Prockop DJ, Shioda S
  • Organizer: 10th International Congress of Neuroimmunology (ISNI 2010)
  • Place of Presentation: Sites, Spain
  • Year and Date: 20101000
• [Presentation] The roles of Gp91phox (NOX2) expressed in classical activated microglia after traumatic brain injury. (2010)
  • Author(s): Dohi K, Ohtaki H, Kazue S, Nakamachi T, Yofu S, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
  • Organizer: 10th International Congress of Neuroimmunology (ISNI 2010)
  • Place of Presentation: Sites, Spain
  • Year and Date: 20101000
• [Presentation] Interleukin-1 influence microglia/macrophage activation after spinal cord injury in mice. (2010)
  • Author(s): Sato A, Ohara K, Ohtaki H, Atsumi T, Shioda S
  • Organizer: 10th International Congress of Neuroimmunology (ISNI 2010)
  • Place of Presentation: Sites, Spain
  • Year and Date: 20101000
• [Presentation] Human MSCs decrease nitric oxide release from microglia. (2010)
  • Author(s): Ohtaki H, Song D, Kobayashi N, Dohi K, Shioda S
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA
  • Year and Date: 20101000
• [Presentation] Activation of microglia lead to onset of Parkinson disease animal model. (2010)
  • Author(s): Ishii A, Tanaka S, Ohtaki H, Nakamachi T, Numazawa S, Shioda S, Yoshida T
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA
  • Year and Date: 20101000
• [Presentation] Human MSCs modified classical activation in microglial cells. (2010)
  • Author(s): Ohatki H, Murakami T, Song D, Sato A, Dohi K, Shioda S
  • Organizer: International society for stem cell research (ISSCR) 8^<th> Annual Meeting
  • Place of Presentation: San Francisco, CA
  • Year and Date: 20100600
• [Presentation] Deficient of learning and memory in aged PACAP-deficient mice. (2010)
  • Author(s): Shioda S, Nakamachi T, Ohtaki H, Arata S
  • Organizer: 7th Joint meeting of the European Neuropeptide Club and the Summer Neuropeptide Conference
  • Place of Presentation: Pecs, Hungary
  • Year and Date: 20100600
• [Presentation] 新規ドライアイ疾患モデル動物としてのPACAP遺伝子欠損マウスの評価 (2010)
  • Author(s): 中町智哉、会沢洋一、大滝博和、関 保、遠藤貴美、荒田悟、新谷紀人、橋本均、馬場明道、塩田清二
  • Organizer: 第57回日本実験動物学会
  • Place of Presentation: 京都
  • Year and Date: 20100500
• [Presentation] 骨髄幹細胞による神経保護作用とマイクログリア制御機構(シンポジウム) (2010)
  • Author(s): 大滝博和
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] PACAP遺伝子欠損マウスにおける涙液分泌機能異常 (2010)
  • Author(s): 中町智哉、会沢洋一、大滝博和、養父佐知子、関保、遠藤貴美、荒田悟、新谷紀人、橋本均, 馬場明道、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] Immunohistochemical localization of PACAP and PAC-1 receptors in mouse salivary glands. (2010)
  • Author(s): 野中直子、中町智哉、塩田清二、中村雅典
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] マウス精巣におけるPKCδの組織分布 (2010)
  • Author(s): 中町智哉、新野由子、小倉 潔、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] 海馬歯状回原基のGFAP発現神経幹細胞のニューロン分化について (2010)
  • Author(s): 石龍徳、大隅典子、井村徹也、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] 頭部外傷後のcytotoxic microgliaにおけるgp91phoxの発現と役割 (2010)
  • Author(s): 土肥謙二、大滝博和、佐藤和恵、中町智哉、養父佐知子、宋丹丹、村上朋恵、宮本和幸、塩田清二、有賀徹
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] インターロイキン1遺伝子欠損マウスにおける脊髄損傷後の神経炎症反応抑制効果 (2010)
  • Author(s): 佐藤敦、小原賢司、大滝博和、安藤美貴子、渥美敬、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] NMDA誘導性網膜障害マウスに対するPACAPの保護効果 (2010)
  • Author(s): 遠藤貴美、中町智哉、関保、加賀美信幸、中村圭輔、市橋陽子、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 20100300
• [Presentation] Modulation of immune response by PACAP and MSCs is a therapeutic strategy for neural injury (Symposist). (2010)
  • Author(s): 大滝博和
  • Organizer: Official satellite symposium of the 14th International Congress of Endocrinology (ICE2010) (GPCR2010)
  • Place of Presentation: Kyoto
  • Year and Date: 20100300
• [Presentation] Somatolactin release from cultured goldfish pituitary cells is regulated by PACAP and MCH. (2010)
  • Author(s): Azuma M, Tanaka M, Saito Y, Uchiyama M, Takahashi A, Shioda S, Matsuda K
  • Organizer: Official satellite symposium of the 14th International Congress of Endocrinology (ICE2010) (GPCR2010)
  • Place of Presentation: Kyoto
  • Year and Date: 20100300
• [Presentation] Neuroprotection by PACAP and MSCs in ischemic brain. (2009)
  • Author(s): Shioda S, Nakamachi T, Ohtaki H, Dohi K, Nonaka N, Banks WA
  • Organizer: The Israel Society for Neuroscience8th Annual Meeting
  • Place of Presentation: Eilat(Invited lecture)
  • Year and Date: 20091100
• [Presentation] ラット高眼圧モデルにおける神経ペプチドPACAPによる神経節細胞死抑制効果の評価 (2009)
  • Author(s): 伊東宏之、関保、中町智哉、塩田清二
  • Organizer: 第56回昭和医学会総会
  • Place of Presentation: 東京
  • Year and Date: 20091100
• [Presentation] The expression and the localization of orexin-1 receptor (OX1R) after traumatic brain injury in mice. (2009)
  • Author(s): Mihara Y, Dohi K, Yofu S, Nakamachi T, Kageyama H, Shioda S, Aruga T
  • Organizer: Yakushima 2009 (Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 20091000
• [Presentation] PACAP induces neural progenitor cell differentiation toward glial lineage in vivo. (2009)
  • Author(s): Watanabe J, Nakamachi T, Nakamura M, Nakajo S, Shioda S
  • Organizer: Yakushima 2009 (Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima Kagoshima
  • Year and Date: 20091000
• [Presentation] Endogenous PACAP as a cardioprotectant in Doxorubicin-induced cardiomyopathy model in mice. (2009)
  • Author(s): Mori H, Nakamachi T, Ohtaki H, Hasegawa F, Yofu S, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S
  • Organizer: Yakushima 2009 (Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 20091000
• [Presentation] Regulation of somatolactin release from cultured goldfish pituitary cells by PACAP and MCH. (2009)
  • Author(s): Azuma M, Tanaka M, Saito Y, Uchiyama M, Takahashi A, Shioda S, Matsuda K
  • Organizer: Yakushima 2009 (Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates o Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 20091000
• [Presentation] Neuroprotective effect of endogenous PACAP against focal cerebral ischemia in mice. (2009)
  • Author(s): Nakamachi T, Ohtaki H, Nonaka N, Banks WA, Shioda S
  • Organizer: Yakushima 2009 (Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 20091000
• [Presentation] Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on the survival of ganglion cells in the rat retina after intraocular hypertension. (2009)
  • Author(s): Itoh H, Seki T, Nakamachi T, Endo K, Shioda S
  • Organizer: Yakushima 2009 (Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 20091000
• [Presentation] Neuroprotective strategy on brain injuries by immunemodulation-Lesson from PACAP and hMSCs on stroke-. (2009)
  • Author(s): Ohtaki H, Nakamachi T, Dohi K, Shioda S
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Kagoshima
  • Year and Date: 20091000
• [Presentation] Delivery of pituitary adenylate cyclase activating polypeptide (PACAP) to the brain : targeting with intranasal delivery and cyclodextrins. (2009)
  • Author(s): Nonaka N, Nakamachi T, Shioda S, Banks WA
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Kagoshima
  • Year and Date: 20091000
• [Presentation] Effect of PACAP on tear secretion in mouse. (2009)
  • Author(s): Nakamachi T, Aizawa Y, Ohtaki H, Yofu S, Seki T, Endo K, Nakamura K, Kagami N, Arata S, Shintani N, Hashimoto H, Baba A, Shioda S
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Kagoshima
  • Year and Date: 20091000
• [Presentation] Endogenous PACAP attenuated doxorubicin-induced myocardial damage. (2009)
  • Author(s): Mori H, Nakamachi T, Ohtaki H, Hasegawa F, Yofu S, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Kagoshima
  • Year and Date: 20091000
• [Presentation] Suppression of oxidative stress by PACAP. (2009)
  • Author(s): Sato A, Ohtaki H, Dohi K, Nakamachi T, Yofu S, Ohara K, Hashimoto H, Murakami T, Ando M, Shintani N, Baba A, Shioda S
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Kagoshima
  • Year and Date: 20091000
• [Presentation] Regulation of somatolactin release from cultured goldfish pituitary cells, by PACAP and MCH. (2009)
  • Author(s): Azuma M, Tanaka M, Saito Y, Uchiyama M, Takahashi A, Shioda S, Matsuda K
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Kagoshima
  • Year and Date: 20091000
• [Presentation] Observation of the longevity gene product, SIRT1 immunoreactivity in the developing mouse nervous system. (2009)
  • Author(s): Ogawa T, Wakai C, Saito T, Murayama A, Mimura Y, Youfu S, Kuwagata M, Nakamachi T, Sato K, Shioda S
  • Organizer: The 39th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, IL
  • Year and Date: 20091000
• [Presentation] Neuroprotective effect of endogenous PACAP against ischemic damage ; Target on peptide transport system-6. (2009)
  • Author(s): Nakamachi T, Ohtaki H, Nonaka N, Banks WA, Shioda S
  • Organizer: The39th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, IL
  • Year and Date: 20091000
• [Presentation] How do GFAP-expressing neural progenitors divide and generate neuron-committed progeny in the postnatal hippocampus? (2009)
  • Author(s): Seki T, Namba T, Liu Y, Shioda S
  • Organizer: The 39th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, IL
  • Year and Date: 20091000
• [Presentation] Distribution of activity-dependent neuroprotective protein (ADNP) and PAC1 receptor in intact and ischemic mouse brain. (2009)
  • Author(s): Nakamachi T, Kagami N, Yofu S, Endo K, Nakamura K, Wada Y, Hori M, Arata S, Shioda S
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA
  • Year and Date: 20091000
• [Presentation] Neuroprotection and molecular mechanism of PACAP in brain ischemia. (2009)
  • Author(s): Shioda S, Nakamachi T, Ohtaki H, Dohi K, Nonaka N, Banks WA
  • Organizer: Neuropeptide Festival 2009, Joint Meeting of the European Neuropeptide Culb and Summer Neuropeptide Conference
  • Place of Presentation: Salzburg, Austria
  • Year and Date: 20090700
• [Presentation] Human adult stem/progenitor cells from bone marrow protect hippocampal neurons by communicating with microglia after transient global ischemia of mice. (2009)
  • Author(s): Ohtaki H, Ylostalo J, Foraker JE, Robinson AP, Reger RL, Shioda S, Prockop DJ
  • Organizer: International society for stem cell research (ISSCR) 7th Annual Meeting
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20090700
• [Presentation] Evolution of PACAP signaling in vertebrates (Symposium). (2009)
  • Author(s): Shioda S, Nakamachi T, Ohtaki H, Matsuda K
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090600
• [Presentation] PACAP and MCH regulates somatolactin release from cultured goldfish pituitary cells. (2009)
  • Author(s): Azuma M, Tanaka M, Saito Y, Uchiyama M, Mizusawa K, Takahashi A, Shioda S, Matsuda K
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090600
• [Presentation] 内因性PACAPによる虚血性神経細胞死抑制作用の解析 (2009)
  • Author(s): 中町智哉、大滝博和、養父佐知子、野中直子、塩田清二、他1名
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20090300
• [Presentation] 骨髄間葉系幹細胞は免疫応答の調節により虚血性神経細胞死を抑制する (2009)
  • Author(s): 大滝博和、Ylostalo JE、塩田清二、Prockop DJ
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20090300
• [Presentation] マウスのドキソルビシン心筋障害モデルにおけるPituitary Adenylate Cyclase Activating Polypeptide(PACAP)の心筋保護効果 (2009)
  • Author(s): 森敬善、中町智哉、大滝博和、馬場明道、塩田清二、他6名
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20090300
• [Presentation] 反応性アストロサイトにおけるPACAP受容体発現とその機能的意義の解析 (2009)
  • Author(s): 中町智哉、養父佐知子、大滝博和、森敬善、塩田清二、他2名
  • Organizer: 114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20090300
• [Presentation] マウスのドキソルビシン心筋障害モデルにおけるPituitary Adenylate Cyclase Activating Polyeptide(PACAP)の心筋保護効果 (2009)
  • Author(s): 森敬善、中町智哉、大滝和博、馬場明道、塩田清二
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20090300
• [Presentation] 反応性アストロサイトにおけるPACAP受容体発現とその機能的意義の解析 (2009)
  • Author(s): 中町智哉、押田佳菜子、養父佐知子、大滝博和、森敬善、佐藤敦、塩田清二
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20090300
• [Presentation] Endogenous PACAP protects the brain against focal cerebral ischemia in mice (Symposium). (2009)
  • Author(s): Nakamachi T, Ohtaki H, Nonaka N, Banks WA, Shioda S, 他1名
  • Organizer: 17^<th> International Symposium on Regulatory Peptides
  • Place of Presentation: Santa Barbara
  • Year and Date: 20090100
• [Presentation] Endogenous PACAP protects the brain against focal cerebral ischemia in mice. (2009)
  • Author(s): Nakamachi T, Ohtaki H, Yofu S, Nonaka N, Banks WA, Shioda S
  • Organizer: 17th International Symposium n Regulatory Peptides
  • Place of Presentation: Santa Barbara, CA
  • Year and Date: 20090100
• [Presentation] マウス涙腺組織におけるPACAP/PAC1受容体の分布局在と機能解析 (2008)
  • Author(s): 中町智哉、大滝博和、養父佐知子、渡邊潤、塩田清二, 他2名
  • Organizer: 第33回日本比較内分泌学会大会及びシンポジウム
  • Place of Presentation: 広島
  • Year and Date: 20081200
• [Presentation] Humanadult stem/progenitor cekks from bone marrow (hMSCs) suppress ischemic neuronal death through microglia. (2008)
  • Author(s): Ohtaki H, Ylostalo J, Foraker JE, Shioda S, Prockop DJ, 他2名
  • Organizer: The 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 20081100
• [Presentation] Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates proliferation of reactive astrocyte in vitro. (2008)
  • Author(s): Nakamachi T, Yofu S, Mori H, Ohtaki H, Shioda S, 他3名
  • Organizer: The 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 20081100
• [Presentation] Neuroprotective effect of PACAP and the mechanisms : therapeutic effects in Stroke models (Symposium). (2008)
  • Author(s): Nakamachi T, Ohtaki H, Nonaka N, Banks WA, Shioda S
  • Organizer: Showa University International Symposium for Life Science 5^<th> Annual Meeting
  • Place of Presentation: Tokyo
  • Year and Date: 20080900
• [Presentation] Involvement of IL-1 in lipopolysaccharide-induced impairment of learning and memory in mice (Symposium). (2008)
  • Author(s): Tanaka S, Kanda K, Nakamachi T, Shioda S, Yoshida T, 他1名
  • Organizer: Showa University International Symposium for Life Science 5^<th> Annual Meeting
  • Place of Presentation: Tokyo
  • Year and Date: 20080900
• [Presentation] Increased behavioral activity with regular circadian mice (Symposium). (2008)
  • Author(s): Arata S, Hosono T, Kageyama H, Nakamachi T, Shioda S
  • Organizer: Showa University International Symposium for Life Science 5^<th> Annual Meeting
  • Place of Presentation: Tokyo
  • Year and Date: 20080900
• [Presentation] Expression and localization of pituitary adenylate cyclase-activating polypeptide-specific receptor (PACAP) after traumatic brain injury in mice. (2008)
  • Author(s): Morikawa K, Yofu S, Nakamachi T, Shioda S, Aruga T, 他2名
  • Organizer: Showa University International Symposium for Life Science 5^<th> Annual Meeting
  • Place of Presentation: Tokyo
  • Year and Date: 20080900
• [Presentation] Neuroprotection and the molecular mechanism of Pituitary adenylate cyclase-activating polypeptide (PACAP) in brain ischemia (Symposium). (2008)
  • Author(s): Shioda S, Nakamachi T, Ohtaki H, Dohi K, Nonaka N, 他1名
  • Organizer: First meeting of the Japan Branch of the International Neuropeptide Society ; International Symposium on Biologically Active Peptides : Peptide Diversity
  • Place of Presentation: Sendai
  • Year and Date: 20080800
• [Presentation] 下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP)の神経幹細胞に対する作用 (2008)
  • Author(s): 中町智哉、渡邊潤、大滝博和、養父佐知子、塩田清二
  • Organizer: 第35回日本下垂体研究会合同学術集会
  • Place of Presentation: 東京
  • Year and Date: 20080800
• [Presentation] Human adult stem/progenitor cells from bone marrow (hMSCs) decrease neuronal cell death in global ischemia by modulation of the immune response. (2008)
  • Author(s): Ohtaki H, Ylostalo J, Foraker JE, Shioda S, Prockop DJ, 他2名
  • Organizer: 第31回に本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080700
• [Remarks] ホームページ等