2010 Fiscal Year Final Research Report
Elucidation of functional significance of caveola in periodontal mechanoreceptor
| Project/Area Number |
20390464
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Kenji 新潟大学, 医歯学系, 准教授 (80242436)
INOUE Kayoko 新潟大学, 医歯学系, 特任准教授 (90303130)
KAWANO Yoshiro 新潟大学, 医歯学系, 助教 (60303129)
SUZUKI Akiko 新潟大学, 医歯学系, 特任助教 (70509538)
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| Project Period (FY) |
2008 – 2010
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| Keywords | カベオラ / カベオリン / 機械受容 / 歯根膜ルフィニ神経終末 / カルシウムイオン |
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| Research Abstract |
The Ruffini endings, a primary mechanoreceptor in the periodontal ligament, well-develop caveolae in their cell membrane. The present study examined the functional significance of caveolae in the periodontal Ruffini endings. The caveolae were consisted of caveolin-1 with diverse functions. A unique immuno-localization pattern of caveolin-1 and Ca^<2+>-pump suggested caveolae is involved in the quick elimination of intracellular Ca^<2+> which influx into the axon terminals in mechanotransduction.
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