2011 Fiscal Year Final Research Report
Role of ER stress response in the oral cancer
Project/Area Number |
20390477
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | The University of Tokyo |
Principal Investigator |
NISHITOH Hideki 東京大学, 大学院・薬学系研究科, 特任研究員 (00332627)
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Project Period (FY) |
2008 – 2011
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Keywords | 実験腫瘍学 |
Research Abstract |
It is hypothesized that endoplasmic reticulum stress-induced apoptosis may be inhibited in cancer cells and endoplasmic reticulum stress response may be enhanced to induce the cancer cell survival. In this project, we identifies the role of endoplasmic reticulum stress-induced apoptosis and endoplasmic reticulum stress response in the oral cancer cells.
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[Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response2010
Author(s)
Maruyama T., Kadowaki H., Okamoto N., Nagai A., Naguro I., Matsuzawa A., Shibuya H., Tanaka K., Murata S., Takeda K., Nishitoh H., Ichijo H.
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Journal Title
EMBO J
Volume: 29
Pages: 2501-2514
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[Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis2009
Author(s)
Iriyama T., Takeda K., Nakamura H., Morimoto Y., Kuroiwa T., Mizukami J., Umeda T., Noguchi T., Naguro I., Nishitoh H., Saegusa K., Tobiume K., Homma T., Shimada Y., Tsuda H., Aiko S., Imoto I., Inazawa J., Chida K., Kamei Y., Kozuma S., Taketani Y., Mats
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Journal Title
EMBO J
Volume: 28
Pages: 843-853
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[Journal Article] A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants
Author(s)
Fujisawa T., Homma K., Yamaguchi N., Kadowaki H., Tsuburaya N., Naguro I., Matsuzawa A., Takeda K., Takahashi Y., Goto J., Tsuji S., Nishitoh H., Ichijo H.
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Journal Title
Ann. Neurol
Volume: (in press)
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[Journal Article] STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein
Author(s)
Sato T., Sako Y., Sho M., Momohara M., Suico M. A., Shuto T., Nishitoh H., Okiyoneda T., Kokame K., Kaneko M., Taura M., Miyata M., Chosa K., Koga T., Morino-Koga S., Wada I., Kai H.
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Journal Title
Mol. Cell
Volume: (in press)
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