Nobel domestic gene therapy against tumor angiogenesis with decoy strategy.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390478
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Shimane University
• Principal Investigator: ISHIBASHI Hiroaki Shimane University, 医学部, 准教授 (90254630)
• Project Period (FY): 2008 – 2011
• Keywords: 口腔がん / 血管新生 / 遺伝子治療

Research Abstract

腫瘍の増殖に必須とされるる血管新生は腫瘍細胞から産生される血管新生因子が周囲組織の血管を活性化することで開始され,多段階の血管新生過程により達成される.近年,腫瘍細胞の血管新生因子発現の誘導にサイトカインや微小環境の変化が関与しているという報告が蓄積されてきた.そこで,本研究では極めて安全な純国産型ウイルスベクターを用いて,癌細胞におとり遺伝子を導入し,複数の血管新生因子群を同時に抑制するという全く新しい概念に基づく,本邦独自の純国産型といえる新規癌遺伝子治療法の開発を目的とする

Research Products

• [Journal Article] A fish bone in the tongue : a report of a case (2010)
  • Author(s): Nariai Y, Yanai C, Kondo S, Ishibashi H, Egawa M, Kitagaki H, Sekine J
  • Journal Title: Asian J Oral Maxillofac Surg 22 Pages: 30-32
• [Journal Article] Our approach for early detection of oral cancer using smear cytology. (2010)
  • Author(s): Kikuchi M, Ishibashi H, Kondo S, Fujihara S, Karino M, Tatsumi H, Yoshino A, Enomoto Y, Nariai Y, Sekine J
  • Journal Title: Journal of the Korean Association of Oral and Maxillofacial Surgeons 36 Supplement No.1 Pages: 315-316
• [Journal Article] Use of TCP plates in condylar fracture osteosynthesis. (2010)
  • Author(s): Yanai C, Nariai Y, Kondo S, Tatsumi H, Ishibashi H, Sekine J
  • Journal Title: International Proceedings of 20th Congress of the European Association of Cranio-Maxillo-Facial Surgery. Pages: 35-37
• [Journal Article] Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells. (2009)
  • Author(s): Matsuura M, Onimaru M, Yonemitsu Y, Suzuki H, Nakano T, Ishibashi H, Shirasuna K, Sueishi K
  • Journal Title: Am J Pathology 174 Pages: 361-368
• [Journal Article] Management of tongue squamous cell carcinoma in pregnant women : Report of two Patients. (2009)
  • Author(s): Kondo S, Ishibashi H, Nariai Y, Kato T, Enomoto Y, Karino M, Sekine J
  • Journal Title: Asian J Oral Maxillofac Surg 21 Pages: 129-132
• [Journal Article] Feasible technique for the prediction of lymph node involvement in squamous cell carcinoma of the tongue by nuclear morphometric analysis. (2009)
  • Author(s): Karino M, Ishibashi H, Fujihara S, Watanabe M, Ichiba Y, Nariai Y, Kondo S, Sekine J
  • Journal Title: Proceedings of the 19th International Conference on Oral and Maxillofacial Surgery 38(5) Pages: 426
• [Journal Article] Feasible technique for the prediction of lymph node involvement in squamous cell carcinoma of the tongue by nuclear morphometric analysis. (2009)
  • Author(s): Karino M, Ishibashi H, Fujihara S, Watanabe M, Ichiba Y, Nariai Y, Kondo S, Sekine J
  • Journal Title: The 55th Annual Congress of the Japan Section, Proceedings 36
• [Journal Article] Our surgical management of odontogenic tumor. (2009)
  • Author(s): Higashi T, Ishibashi H, Kato T, Karino M, Yoshino A, Nariai Y, Kondo S, Yanai C, Sekine J
  • Journal Title: The International College of Surgeons, The 55th Annual Congress of the Japan Section, Proceedings 37