2010 Fiscal Year Final Research Report
Study for Clarification of Mechanism of Bisphosphonate-related Osteonecrosis of the Jaw and Development of Its Treatment.
| Project/Area Number |
20390485
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGAKI Yuko 神奈川歯科大学, 歯学部, 教授 (60050689)
SAKURAI Takashi 神奈川歯科大学, 歯学部, 准教授 (60277910)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Bisphosphonate / 顎骨壊死 / Alendronate |
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| Research Abstract |
Following ovariectomy(OVX) and oral administration of bisphosphonates(BPs : Alendronate), the upper first molars of female ICR mice were drilled to induce the pulpal exposure and subsequently observed. Consequently, & CT analysis of apical lesion demonstrated that bone resorption in the periapical lesion increased in area in the group of OVX+BPs compared with the group of OVX. Thus, it is suggested that the occurrence of peculiar lesion in jaws is attributed to the difference of speed in bone metabolism in contrast with general bones and the high deposition of BPs onto bone matrix.
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