2010 Fiscal Year Final Research Report
The development and application of composite functional medical device using new biodegradable magnesium alloy
| Project/Area Number |
20390496
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MUKAI Toshiji 独立行政法人物質・材料研究機構, 新構造材料センター, グループリーダー (40254429)
YAMAMOTO Akiko 独立行政法人物質・材料研究機構, 生体材料センター, グループリーダー (20343882)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マグネシウム合金 / 生体吸収性 / 骨形成 / 動物実験 |
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| Research Abstract |
To apply biodegradable magnesium alloy for medical device, its biocompatibility and absorption velocity were examined in vitro and in vivo. In vitro, elevated activity of alkaline phosphatase was confirmed in osteoblast by magnesium ion addition. Magnesium alloy revealed the relationship between the degradation velocity and amount of gas formation. There was no pathological change in skin and bone tissue around magnesium alloy. The newly bone formation around magnesium alloy implant was seen in vivo examination. The biocompatibility and bone formation of magnesium alloy were confirmed by these results.
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