2010 Fiscal Year Final Research Report
Preparation of Bioresorbable Nanoporous Fibermats for Bone Regeneration in a Dental Field
| Project/Area Number |
20390497
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
KASUGA Toshihiro Nagoya Institute of Technology, 工学研究科, 教授 (30233729)
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| Co-Investigator(Kenkyū-buntansha) |
BAN Seiji 愛知学院大学, 歯学部, 非常勤講師 (10159105)
OBATA Akiko 名古屋工業大学, 工学研究科, 助教 (40402656)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨再生誘導法 / 炭酸カルシウム / ポリ乳酸 / アパタイト / 電界紡糸法 / ナノポーラス繊維 / 不織布 / 歯科治療 |
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| Research Abstract |
Novel bioresorbable materials with silicate and calcium ions-releasing ability for enhancing bone formation were prepared using composites consisting of siloxane, poly (lactic acid) and calcium carbonate. They could be shaped into nonwoven fibermats of 100～200μm-thickness, consisting of nanoporous fibers of～10μm in diameter. Cell culture tests showed that this dimensional design induced the 3D proliferation of bone-forming cells. The materials were confirmed by animal tests using rabbits to show excellent bone formation. They are expected to be applicable to membranes for guided bone regeneration in a dental field.
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