2010 Fiscal Year Final Research Report
Evaluation of potential to promote the differentiation of osteoblastic cells by immobilized cationic antimicrobial peptide, JH8194 which promotes the proliferation of mesenchymal stem cells
| Project/Area Number |
20390499
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
NIKAWA Hiroki Hiroshima University, 大学院・医歯薬総合研究科, 教授 (10228140)
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| Co-Investigator(Kenkyū-buntansha) |
MAKIHIRA Seicyo 九州大学, 大学院・歯学研究院, 准教授 (80304450)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 塩基性ペプチド / チタン / インプラント / 骨芽細胞 / オッセオインテグレーション |
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| Research Abstract |
The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration
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