Development of therapy targeting orphan GPCR-related lipid mediators for prevention of bone destruction

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390508
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: HIKIJI Hisako Kyushu Dental College, 歯学部, 教授 (50292876)
• Project Period (FY): 2008 – 2010
• Keywords: 骨吸収性疾患 / 脂質リガンド / 脂質リガンド / オーファン受容体

Research Abstract

(1)骨吸収関連GPCRを選定する。
(2)その受容体欠損マウスを作成し、in vivo, in vitroで骨吸収作用の解析を行う。
(3)さらに当該受容体のアンタゴニスト・アゴニストを用いて、病態マウスモデルに対し、治療薬開発の可能性を検討する。

Research Products

• [Journal Article] Perspectives on a new educational system for dental hygiene students in Japan. (2011)
  • Author(s): Hikiji1 H, Kubota K, Takahashi Y, Kanehisa Y, Yoshino K, Sonoki K, Chiwata K, Inoue H, Tsujisawa T, Akiifusa S, Kakinoki Y, Nishihara T, Fukuta J.
  • Journal Title: J.Dent.Edu. 75 Pages: 563-571
• [Journal Article] Evaluation and analysis of formation of bone at the palate in patients with cleft lip and palate after palatoplasty based on computed tomograms and three-dimensional data. (2010)
  • Author(s): Saijo H, Mori Y, Fujihara H, Kanno Y, Chikazu D, Ohkubo K, Hikiji1 H, Iino M, Yonehara Y, Takato T.
  • Journal Title: Scand J Plast Reconstr Surg Hand Surg. 44(1) Pages: 21-25
• [Journal Article] Improvement in wound healing by a novel synthetic collage-gel dressing in genetically diabetic mice. (2010)
  • Author(s): Chikazu D, Taguchi T, Koyama H, Hikiji1 H, Fujihara H, Suenaga H, Saijo H, Mori Y, Seto I, Iino M, Takato T.
  • Journal Title: Asian. J.Oral.Maxillofac. Surg. 22 Pages: 61-67
• [Journal Article] 脂質メディエーターと骨代謝 (2010)
  • Author(s): 引地尚子
  • Journal Title: 九州歯会誌 64(3) Pages: 59-65
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. (2009)
  • Author(s): Hikiji1 H, Ishii S, Yokomizo T, Takato T, Shimizu T.
  • Journal Title: Proc Natl Acad Sci U S A. 106 Pages: 21294-21299
• [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. (2008)
  • Author(s): Hikiji1 H, Takato T, Shimizu T, Ishii S
  • Journal Title: Progress Lipid Res. 47 Pages: 107-126
• [Journal Article] A case of tumoural calcinosis in the temporomandibular joint associated with systemic sclerosis. (2008)
  • Author(s): Chikazu D, Mori Y, Saijo H, Fujihara H, Ko E.C, Hikiji1 H, Yonehara Y, Takato T.
  • Journal Title: Int.J.Oral Maxillofac. Surg. 37(2) Pages: 190-193
• [Journal Article] Metastasis of prostate cancer to the mandibular condyle. (2008)
  • Author(s): Saijo H, Chikazu D, Mori Y, Hikiji1 H, Yonehara Y, Takato T.
  • Journal Title: Asian.J.Oral.Maxillofac. Surg. 20 Pages: 86-88
• [Journal Article] Reiter's syndrome (reactive arthritis) with trismus after intravesical BCG immunotherapy : A case report.
  • Author(s): Hatano N, Hikiji1 H, Matsubara M, Saijo H, Chikazu D, Ohashi K, Mori Y, Susami T, Yoda T, Takato T.
  • Journal Title: Asian.J.Oral.Maxillofac. Surg in press
• [Presentation] Oral Health Care Training in the New Dental Hygiene Education Curriculum in Japan. (2010)
  • Author(s): 引地尚子
  • Organizer: 第58回国際歯科研究学会(JADR)総会・学術大会
  • Year and Date: 20101120-20101121
• [Presentation] 口腔外科手術後の口腔ケアに対するリスクアセスメント (2010)
  • Author(s): 引地尚子, 高橋由希子, 山下善弘, 冨永和宏, 高橋哲, 福田仁一
  • Organizer: 第55回日本口腔外科学会総会
  • Place of Presentation: 千葉
  • Year and Date: 20101016-18
• [Presentation] ロイコトリエンB4受容体BLT1の骨吸収機能の解析 (2010)
  • Author(s): 引地尚子
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京
  • Year and Date: 20100721-23
• [Presentation] The leukotriene B4 receptor BLT1 in osteoclasts plays an important role in bone loss. (2010)
  • Author(s): Hikiji H, Ishii S, Yokomizo T, Shimizu T
  • Organizer: FASEB Summer Research Conferences. Phospholipid Metabolism : Disease, Signal Transduction, and Membrane Dynamics.
  • Place of Presentation: Steamboat Springs, Colorado
  • Year and Date: 20100627-20100702
• [Presentation] 右側上顎犬歯部歯肉に生じた腺腫様歯原性腫瘍の1例 (2010)
  • Author(s): 齋藤健太郎, 森良之, 引地尚子, 菅野勇樹, 杉山円, 前田祐二郎, 宇波雅人, 末永英之, 阿部雅修, 古賀陽子, 大久保和美, 西條英人, 近津大地, 高戸毅
  • Organizer: 第64回日本口腔科学会総会
  • Place of Presentation: 北海道
  • Year and Date: 2010-06-24
• [Presentation] 骨吸収におけるロイコトリエンB4受容体BLT1の機能解析 (2009)
  • Author(s): 引地尚子, 石井聡, 横溝岳彦, 清水孝雄
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 20091021-24
• [Presentation] 東京大学医学部附属病院口腔外科顎関節外来を受診された患者についての臨床統計的考察 (2009)
  • Author(s): 松原稔, 引地尚子, 波田野典子, 西條英人, 近津大地, 森良之, 飯野光喜, 須佐美隆史, 依田哲也, 高戸毅
  • Organizer: 第22回日本顎関節学会総会
  • Place of Presentation: 東京
  • Year and Date: 20090725-26
• [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice (2008)
  • Author(s): Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y., Iino M., Takato T.
  • Organizer: 8th Asian Congress on Oral and Maxillofacial Surgery
  • Year and Date: 20081103-20081107
• [Presentation] 新規コラーゲンゲルとbFGF併用による骨形成促進作用に関する検討 (2008)
  • Author(s): 引地尚子, 近津大地, 西條英人, 小笠原徹, 森良之, 飯野光喜, 須佐美隆史, 高戸毅
  • Organizer: 第53回口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 20081020-21
• [Book] 医師\歯科医師のための口腔診療必携(第1章 7節)(顎の外れを繰り返す患者が来院したら?) (2010)
  • Author(s): 引地尚子
  • Total Pages: 102
  • Publisher: 金原出版