2010 Fiscal Year Final Research Report
PDE2 related signal・gene therapy on oral malignant tumor
| Project/Area Number |
20390513
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University |
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Principal Investigator |
TAGAWA Toshiro Mie University, 大学院・医学系研究科, 教授 (30046346)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Taku 三重大学, 医学部附属病院, 講師 (80242965)
SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 悪性腫瘍 / phosphodiesterase / phosphodiesterase2 / 運動能 |
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| Research Abstract |
Until now we had studied PDE2 of human oral malignant melanoma PMP cells. In this study, we examined PDE2 functions, and PDE2 expressions and characterizations of other malignant tumor cells. PDE2 expressed in a few malignant tumor cells. PDE2 did not relate apoptosis and migration. But, PDE2 related DNA synthesis and it was suggested that PDE2 regulated cell cycle.
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