2010 Fiscal Year Final Research Report
Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines
| Project/Area Number |
20390520
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
SHINTANI Satoru Showa University, 歯学部, 教授 (80294429)
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| Co-Investigator(Kenkyū-buntansha) |
HATORI Masashi 昭和大学, 歯学部, 准教授 (20245814)
ITO DAISUKE 東京医科歯科大学, 硬組織疾患ゲノムセンター, 特任講師 (40286844)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 口腔癌 / テロメラーゼ / ウイルス治療 |
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| Research Abstract |
Telomerase activation is considered to be a critical step in carcinogenesis, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells.
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Research Products
(1 results)
