2011 Fiscal Year Final Research Report
Investigation of the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate
| Project/Area Number |
20390521
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
ONO Takashi 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (30221857)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HONDA Eiichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30192321)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Keywords | 口唇口蓋裂 / 構音 / 中枢 / 末梢 / 磁気共鳴画像法 |
|---|
| Research Abstract |
The overall goal of this study was to elucidate the biological background of speech, and this study was aimed to investigate the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate. Following results were obtained ; 1) Magnetic resonance imaging(MRI) movie was newly developed to investigate the peripheral mechanism for articulation, 2) significant interactions between peripheral articulatory movement(obtained using MRI movie) and brain activation pattern(obtained using fMRI) were found, 3) the cortical activation pattern by tongue sensation was dependent on the side preference of mastication, 4) brain activation pattern in auditory association area for glottal-stop perception was different from normal articulation in healthy subjects.
|
