2010 Fiscal Year Final Research Report
Responses of each cartilaginous layer of mandibular condyle to external stimuli and the association with progressive condylar resorption
| Project/Area Number |
20390523
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANNE Kazuo Hiroshima University, 医歯薬学総合研究科, 教授 (30159032)
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| Co-Investigator(Kenkyū-buntansha) |
TANIMOTO Kotaro 広島大学, 病院, 講師 (20322240)
NOBUAKI Tanaka 広島大学, 大学院・医歯薬学総合研究科, 助教 (90397969)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Superficial zone protein / 下顎頭 / 軟骨 / 成長因子 / サイトカイン |
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| Research Abstract |
The modulation process of superficial zone protein (SZP), a lubricant in temporomandibular joint, was clarified. The expression of SZP was higher in the superficial layer of condylar cartilage than that in other layers. In addition, the expression of SZP was down-regulated by a proinflammatory cytokine, IL-1β, leading to a deterioration of lubrication and degenerative changes in TMJ under inflammatory conditions. Hyaluronan (HA) is a major lubricant in synovila fluid, and low moleculer weight HA was accumulated in TMJ under excessive loading. The synthesis of low moleculer weight HA in synovial membrane cells was up-regulated by IL-1β. At the same time, the degradation of HA by hyaluronidase expressed by synovial membrane cells was enhanced by IL-1β. These results suggested a possible mechanism of fragmentation of HA in TMJ under inflammatory conditions. In addition, it was suggested that low molecular weight HA affects the expression of SZP through cells surface receptor in synovial membrane cells.
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[Journal Article] Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system.2010
Author(s)
Lin YY., Tanaka N., Ohkuma S., Iwabuchi Y., Tanne Y., Kamiya T., Kunimatsu R., Huang YC., Yoshioka M., Mitsuyoshi T., Tanimoto K., Tanaka E., Tanne K.
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Journal Title
Eur J Oral Sci 118
Pages: 151-158
Peer Reviewed
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[Journal Article] The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading.2009
Author(s)
Lin YY, Tanaka N, Ohkuma S, Kamiya T, Kunimatsu R, Huang YC, Yoshioka M, Mitsuyoshi T, Tanne Y, Tanimoto K, Tanaka E, Tanne K.
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Journal Title
Ann Biomed Eng. 37
Pages: 1358-1367
Peer Reviewed
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[Journal Article] The effect of mechanical loading on the metabolism of growth plate chondrocytes2008
Author(s)
Ueki M., Tanaka N., Tanimoto K., Nishio C., Honda K., Lin Y.Y., Tanne Y., Ohkuma S., Kamiya T., Tanaka E., Tanne K.
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Journal Title
Annals of Biomedical Engineering 36
Pages: 793-800
Peer Reviewed
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[Presentation] Modulation of PRG4 expression by hyaluronan through CD44 receptor2010
Author(s)
Mitsuyoshi T., Kamiya T., Tanimoto K., Tanne Y.,Kunimatsu R., Yoshioka M.,Yu-Ching H.,Sano R., Matsuda Y., Yoshimi Y., Tanne K.
Organizer
The 88th International Association for Dental Research
Place of Presentation
Barcelona, Spain
Year and Date
20100714-20100717
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