2011 Fiscal Year Final Research Report
The basic study of effects of bFGF on control of post-operative scarring in cleft palate surgery
| Project/Area Number |
20390526
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Yoshihiko 福岡歯科大学, 歯学部, 教授 (70271666)
TSURUGA Eichi 福岡歯科大学, 歯学部, 准教授 (30295901)
TANIGUCHI Kunihisa 福岡歯科大学, 歯学部, 教授 (90105685)
HATA Yuichiro 福岡歯科大学, 歯学部, 講師 (60465747)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 口蓋裂 / 瘢痕組織 / bFGF / 筋線維芽細胞 / アポトーシス |
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| Research Abstract |
The pharmaceutical modulation may reduce unfavorable effects of scarring after cleft palate surgery by the push-back method. This study investigated the effects of local bFGF administration immediately after mucoperiosteal denudation of rat palates on apoptosis in myofibroblasts, collagen changes and dento-alveolar growth during the wound healing. The results showed that bFGF induces rapid reductions in myofibroblasts, suppresses collagen typeIand elastic system fibers generation, and relieves dental arch constriction in the wound healing process after mucoperiosteal denudation of rat palates. These findings suggest that bFGF has the potential to reduce maxillary growth inhibition after cleft palate surgery by modulating the palatal wound healing process.
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