高齢女性の動脈硬化性疾患予防と健康長寿を目指すアジア老年医学研究

2009 Fiscal Year Annual Research Report

• Project/Area Number: 20406004
• Research Institution: Nagoya University
• Principal Investigator: 林 登志雄 Nagoya University, 医学部付属病院, 講師 (80303634)
• Co-Investigator(Kenkyū-buntansha): 梅垣 宏行 名古屋大学, 医学部附属病院, 助教 (40345898) ; 鈴木 芳克 名古屋市立大学, 医学部附属病院, 准教授 (30254288)
• Keywords: 一酸化窒素 / 動脈硬化症 / 閉経後女性 / エストロゲン / メタボリック症候群 / 遺伝子変異 / 血管内皮細胞

Research Abstract

従前の基盤B海外学術調査(04-06年)を発展させ東アジア3ヶ国(日本、韓国、中国)を中心にアジア各国での高齢女性の生活習慣病(含メタボリック症候群)、動脈硬化性疾患(虚血性心疾患,脳血管障害),認知症等、検査成績、治療状況、食生活、病識、遺伝子変異をフィールド調査し、健康長寿を目指すコホート研究である。ジェンダーに基づく調査拠点の各国への基盤整備も目標とする。今年度は昨年度、共同研究協定を結んだ、韓国Samusung大学産婦人科Byoon主任教授中国四川医科大学老年病科Dong主任教授、(代理Ding准教授)に本邦を訪問頂き以下の調査成績を報告して頂き、本邦の結果と合わせ比較検討を行った。調査項目(1)肥満度,血圧,空腹時血液脂質値,血糖値、HbA1C,肝腎機能,血圧等の基礎指標値,各種ホルモン血中濃度(2)合併症,家族歴、(3)basic及びinstrumental ADL等のCGA(高齢者総合機能評価)、(4)HRTへの期待項目の前回調査項目に加え、(5)腹囲測定を追加,メタボリック症候群発症率(診断基準は各国別とWHO,日本の3法併用)、(6)患者意識,(7)食事,運動量,(8)医療費、(9)living will(終末期を含む医療希望)である。中国約500名、韓国約300名の結果が報告された。興味ある結果として本邦と韓国の遺伝子変異(SNP)分布は血管機能、凝固系にて基本的には極めて相同していたが、韓国女性の成績は半数以上にホルモン補充療法が施行され、施行者における一酸化窒素、エストロゲン受容体、プロトロンビン因子活性のSNPの影響が従前の欧米の報告と異なり顕在化していた。閉経後から前期高齢者が多かったので、今後は、後期高齢者にも発展させる方向とした。四川医科大学老年病科(200床)の電子カルテシステムにCGA項目が採用される等、本研究の高齢者臨床への応用も始まっている。

Research Products

• [Journal Article] Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers (2010)
  • Author(s): Hayashi T, Iguchi A
  • Journal Title: Geriatr Gerontol Int. (印刷中)
  • Peer Reviewed
• [Journal Article] A hydroxymethylglutaryl coenzyme a reductase inhibitor improves endothelial function within 7 days in patients with chronic hemodialysis (2010)
  • Author(s): Kishimoto N, Hayashi T, Sakuma I, Kano-Hayashi H, Tsunekawa T, Osawa M, Ina K, Iguchi A.
  • Journal Title: Int J Cardiol. (印刷中)
  • Peer Reviewed
• [Journal Article] Beneficial effect of the oligomerized polyphenol oligonol on high glucose- induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells (2010)
  • Author(s): Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y.
  • Journal Title: Br J Pharmacol (印刷中)
  • Peer Reviewed
• [Journal Article] Age-Associated Increase in Abdominal Obesity and Insulin Resistance, and Usefulness of AHA/NHLBI Definition of Metabolic Syndrome for Predicting Cardiovascular Disease in Japanese Elderly with Type 2 Diabetes Mellitus (2010)
  • Author(s): Sakurai T, Iimuro S, Araki A, Umegaki H, Ohashi Y, Yokono K Ito H
  • Journal Title: Gerontology (印刷中)
  • Peer Reviewed
• [Journal Article] Pathophysiology of cognitive dysfunction in older people with type 2 dia betel : vascular changes or neurodegeneration? (2010)
  • Author(s): Umegaki H
  • Journal Title: Age Ageing. 39 Pages: 8-10
  • Peer Reviewed
• [Journal Article] Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals : changes in the risk for atherosclerotic diseases at various ages (2009)
  • Author(s): Hayashi T, Kawashima S, Itoh H, 他9名(1番目), on behalf of Japan CDM group
  • Journal Title: Diabetes Care 32 Pages: 1221-1223
  • Peer Reviewed
• [Journal Article] Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women (2009)
  • Author(s): Funami J, Hayashi T, Nomura H, Ding QF, Ishitsuka Watanabe A, Matsui-Hirai H, Ina K, Zhang J, Yu ZY, Iguchi A.
  • Journal Title: Life Sciences 85 Pages: 316-321
  • Peer Reviewed
• [Journal Article] Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet a crossover meal tolerance study (2009)
  • Author(s): Haimoto H, Sasakabe T, Umegaki H Wakai K
  • Journal Title: Nutr Metab (Lond) 6 Pages: 52
  • Peer Reviewed
• [Journal Article] Association of higher carbohydrate intake with depressive mood in elderly diabetic women (2009)
  • Author(s): Umegaki H, Iimuro S, Araki A, Sakurai T, Iguchi A, Yoshimura Y, Ohashi Y, Ito H.
  • Journal Title: Nutr Neurosci. 12 Pages: 267-271
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Hayashi T, Iguchi A.
  • Journal Title: Free radicals as atherosclerotic risk-The relation of NO (Chapter 21)(Elsevier Co.Ltd.) Pages: 673-703 (901)
• [Journal Article] Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats (2008)
  • Author(s): Zhu W, Zhang R, Hu C, Umegaki H.
  • Journal Title: Neuro Endocrinol Lett. 29 Pages: 159-162
  • Peer Reviewed
• [Presentation] Interactions of glucose and insulin in regulation of replicative and stress-induced endothelial senescence―The relationship between telomere and nitric oxide― (2009)
  • Author(s): Hayashi T., Mastsui-Hirai H
  • Organizer: America's Gerontology Society 62nd Annual Scientific Meeting
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2009-11-19
• [Presentation] Depression, Quality of Life and Living will of community-dwelling postmenopausal and elderly women in three asian countries, Japan, Korea and China (2009)
  • Author(s): 伊奈孝一郎, 林登志雄
  • Organizer: 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Pans, France
  • Year and Date: 2009-07-06
• [Presentation] Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals (2009)
  • Author(s): 林登志雄, 他10名(1番目)
  • Organizer: 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris, France
  • Year and Date: 2009-07-05
• [Presentation] Low HDL- cholesterol is associated with the risk of stroke in elderly diabetic in dividuals : Changes in the risk for atherosclerotic diseases at various ages (2009)
  • Author(s): 林登志雄, 他10名(1番目)
  • Organizer: American Diabetes Association's 69th Scientific Sessions
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-06-06
• [Presentation] A new view of atherosclerosis related pharmacogenetics based gene analysis in Japanese elderly women (2009)
  • Author(s): 伊奈孝一郎, 林登志雄
  • Organizer: The 10^<th> International Symposium on Mechanisms of Vasodiatation
  • Place of Presentation: Matsushima, Miyagi, JAPAN
  • Year and Date: 2009-06-02
• [Presentation] Biphsic effects of insulin on endothelial senescence (2009)
  • Author(s): 伊奈孝一郎, 林登志雄
  • Organizer: The 10^<th> International Symposium on Mechanisms of Vasodiatation
  • Place of Presentation: Matsushima, Miyagi, JAPAN
  • Year and Date: 2009-06-02
• [Presentation] 糖尿病罹患者における脳卒中リスクとしての脂質の影響-年齢による危険因子の変化- (2009)
  • Author(s): 伊奈孝一郎, 林登志雄
  • Organizer: 第52回日本糖尿病学会学術集会優秀演題
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] 血管内皮細胞老化におけるグルコースとインシュリンの役割 (2009)
  • Author(s): 林登志雄, 他3名(1番目)
  • Organizer: 第52回日本糖尿病学会学術集会優秀演題
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] 「シトルリン・疾患治療への応用と展望」シトルリン～NO産生と動脈硬化予防への展望 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会 セミナー
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-09
• [Presentation] グルコースとインスリンの細胞老化ストレスを介する動脈硬化への作用 (2009)
  • Author(s): 林登志雄
  • Organizer: 第9回日本NO学術集会 シンポジウムNOとインスリン抵抗性-糖尿病・老化)
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-08
• [Presentation] The role of glucose and insulin on endothelial senescence- The relation of diversity effect of insulin and telomerase- (2009)
  • Author(s): 林登志雄, 他3名(1番目)
  • Organizer: Annual Scientific Meeting American Geriatrics Society
  • Place of Presentation: Chicago USA
  • Year and Date: 2009-05-03