Molecular epidemiological analysis of Giardia intestinalis in Indonesia

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20406007
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Kanazawa University
• Principal Investigator: TOKORO Masaharu Kanazawa University, 医学系, 講師 (30338024)
• Project Period (FY): 2008 – 2010
• Keywords: ランブル鞭毛虫 / ジアルジア / 種内多型 / 分子寄生虫学 / 進化 / 腸管寄生原虫 / インドネシア / 熱帯医学

Research Abstract

ジアルジアGiardia intestinalis(syn.G.duodenalis, G.lamblia)には、多様な種内多型の存在が知られているが、その形成・維持機構は不明である。本研究では、インドネシアの島々に孤立するジアルジアを材料とした遺伝子型解析によって、種内多型とその地理的分布を明らかにするとともに、背景にある多型形成のメカニズムを解明し、進化学的アプローチによる感染症対策に貢献しうる病原体進化の実例を提示することを目指す。

Research Products

• [Journal Article] Split introns in the genome of a divergent eukaryote Giardia intestinalis are excised by spliceosome-mediated trans-splicing (2011)
  • Author(s): Kamikawa R, Inagaki Y, Tokoro M, Roger IA, Hashimoto T.
  • Journal Title: Current Biology. 21(4) Pages: 311-315
  • Peer Reviewed
• [Journal Article] Can humoral host immune responses prevent Giardia infection? : The urinary antibody titers in Indonesian school children XII International (2010)
  • Author(s): Tokoro M, Syafruddin D, Itoh M, Asih P, Rahman M.
  • Journal Title: Congress of Parasitology ICOPA. Pages: 135-138
• [Journal Article] 獲得免疫がジアルジア感染を抑制しているのか? (2010)
  • Author(s): 所正治、伊藤誠、水野哲志、Rahman Moshiur、Din Syafruddin.
  • Journal Title: Recent Advances in Medical Sciences : Parasites and their Human and Animal Hosts Pages: 31-33
• [Journal Article] A case of giardiasis expressing severe systemic symptoms and marked hypereosinophilia. (2010)
  • Author(s): Suzuki Y, Nakamura T, Tokoro M, Togano T, Ohsaka M, Kohri M, Hirata Y, Miyazaki K, Danbara M, Horie R, Miura I, Sunakawa K, Higashihara M.
  • Journal Title: Parasitology International. 59(3) Pages: 487-489
  • Peer Reviewed
• [Journal Article] Multiple-subgenotype infections of Giardia intestinalis detected in Palestinian clinical cases using a subcloning approach. (2009)
  • Author(s): Hussein AI, Yamaguchi T, Nakamoto K, Iseki M, Tokoro M.
  • Journal Title: Parasitology International 58(3) Pages: 258-262
  • Peer Reviewed
• [Presentation] Comprehensive identification of protozoan parasites : distribution of species and genotypes in Sumba Island, Indonesia. (2011)
  • Author(s): Tokoro M, Matsumura T , Hidayati APN, Syafruddin D.
  • Organizer: 45rd Annual U.S.-Japan Joint Conference on Parasitic Diseases
  • Place of Presentation: 国立感染症研究所(東京)
  • Year and Date: 2011-01-12
• [Presentation] Can humoral host immune responses prevent Giardia infection? : The urinary antibody titers in Indonesian school children. (2010)
  • Author(s): Tokoro M, Syafruddin D, Itoh M, Asih P, Rahman M.
  • Organizer: XII International Congress of Parasitology
  • Place of Presentation: Melbourne Convention and Exhibition Center (Australia)
  • Year and Date: 20100815-20100820
• [Presentation] Characteristics of genotype distribution of Giardia intestinalis in an endemic area of Indonesia. (2010)
  • Author(s): Tokoro M, Syafruddin D, Itoh M, Asih P.
  • Organizer: 11^<th> Asian-Pacific Congress for Parasitic Zoonoses
  • Place of Presentation: National Institute of Biological Resources, Incheon (Korea)
  • Year and Date: 2010-10-27
• [Presentation] How has Giardia intestinalis maintained its complex intraspecific diversity? (2009)
  • Author(s): Masaharu Tokoro, Tomohiro Yamaguchi, Amjad I.A. Hussein, Din Syafruddin.
  • Organizer: The 43th Annual U.S.-Japan Joint Conference on Parasitic Diseases
  • Place of Presentation: 国立感染症研究所(東京)
  • Year and Date: 2009-01-08
• [Presentation] Masaharu Tokoro Molecular identification of Entamoeba spp. (2009)
  • Author(s): Kentaro Nakamoto, Miwa Tanaka, Hiroshi Tachibana
  • Organizer: in cynomolgus monkeys and humans The 43th Annual U.S.-Japan Joint Conference on Parasitic Diseases
  • Place of Presentation: 国立感染症研究所(東京)
  • Year and Date: 2009-01-08
• [Book] 外来を訪れる寄生虫症:抗原虫薬:メトロニダゾール、チニダゾール、ST合剤Medical Practice (2010)
  • Author(s): 所正治
  • Total Pages: 438-439
  • Publisher: 文光堂
• [Book] クリプトスポリジウムとジアルジア(第7版)(広範囲血液・尿化学検査・免疫学的検査-その数値をどう読むか-) (2010)
  • Author(s): 所正治、井関基弘
  • Total Pages: 263-266
  • Publisher: 日本臨床
• [Book] ランブル鞭毛虫症(ジアルジア症)その他の原虫症(第3版)(今日の消化器疾患治療指針) (2010)
  • Author(s): 所正治
  • Total Pages: 438-439
  • Publisher: 医学書院
• [Book] 腸管寄生虫症(別冊)(第2版)(新領域別症候群シリーズNo.12消化管症候群-その他の消化器疾患を含めて-) (2009)
  • Author(s): 所正治、竹内勤
  • Total Pages: 70-74
  • Publisher: 日本臨床