Population genetics analysis of Plasmodium vivax-infected erythrocyte surface protein PvSTP

2010 Fiscal Year Final Research Report

• Project/Area Number: 20406009
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: KANEKO Osamu Nagasaki University, 熱帯医学研究所, 教授 (50325370)
• Research Collaborator: JETSUMON Sattabongkot タイ王国在タイ米国陸軍医学研究所, 室長 ; KESINEE Chotivanich タイ王国マヒドン大学, 熱帯医学部, 准教授 ; 曹 雅明 中国医科大学, 医学部, 教授 ; MARCELO Urbano Ferreira ブラジル・サンパウロ大学, 医科学研究所, 教授
• Project Period (FY): 2008 – 2010
• Keywords: 原虫

Research Abstract

Plasmodium vivax PvSTP2 was detected more abundantly than PvSTP1 at the transcription and translation level. PvSTP2 was located on the parasite-infected erythrocyte surface and colocalized with a Schuffner's dots, dot-like structure observed beneath the parasite-infected erythrocyte membrane. Positive diversifying selection was detected on PvSTP1 gene locus and many Vivax malaria patients possessed antibodies against PvSTP1 or PvSTP2.

Research Products

• [Presentation] Antibody response to Plasmodium vivax Subtelomeric Transmembrane Protein (PvSTP), a homolog of Plasmodium falciparum SURFIN, in P. vivax-infected patients (2010)
  • Author(s): Sungkapong T, Yahata K, Culleton R, Tsuboi T, Ruengveerayuth R, Ruengveerayuth R, Sattabongkot J, Udomsangpetch R, Kaneko O, Chotivanich K.
  • Organizer: Joint International Tropical Medicine Meeting 2010 and International Malaria Colloquium 2010
  • Place of Presentation: バンコク、タイ
  • Year and Date: 20101201-20101203
• [Presentation] Plasmodium vivax subtelomeric transmembrane protein 2 (PvSTP2), a homolog of P. falciparum SURFIN : transcription and localization (2010)
  • Author(s): 金子修
  • Organizer: XII Brazilian Meeting on Malaria Research
  • Place of Presentation: オウロプエルト、ブラジル
  • Year and Date: 20101003-20101006
• [Presentation] 三日熱マラリア原虫PvSTPの解析 (2010)
  • Author(s): Sungkapong T,矢幡一英,Chotivanch K,金子修
  • Organizer: 第18回分子寄生虫学
  • Place of Presentation: ワークショップ、草津
  • Year and Date: 20100802-20100805
• [Presentation] Plasmodium SURFIN : evolution, polymorphism, and human sera reactivity (2010)
  • Author(s): 金子修
  • Organizer: Nagasaki Singapore Symposium
  • Place of Presentation: シンガポール
  • Year and Date: 20100415-20100417
• [Presentation] Plasmodium SURFIN : evolution, polymorphism, and human sera reactivity (2009)
  • Author(s): 金子修
  • Organizer: The 4th Nagasaki Symposium on Tropical and Emerging Infectious Diseases
  • Place of Presentation: 長崎
  • Year and Date: 20091126-20091128
• [Presentation] Positive diversifying selection on Plasmodium falciparum SURFIN_<4.1> (2009)
  • Author(s): Xangsayarath P, Kaewthamasorn M, Yahata K, Nakazawa S, Kaneko O
  • Organizer: 第50回日本熱帯医学会大会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20091023-20091024
• [Presentation] Polymorphism patterns of Plasmodium vivax subtelomeric transmembrane protein 1 (PvSTP1) among China field isolates. (2009)
  • Author(s): Zhu XT, Kaewthamasorn M, Yahata K, Cao YM, Kaneko O
  • Organizer: 第50回日本熱帯医学会大会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20091023-20091024
• [Presentation] Diversity of Plasmodium falciparum SURFIN_<4.2> in Thai field isolates (2009)
  • Author(s): Kaewthamasorn M, Yahata Y, Alexandre JSF, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O
  • Organizer: 第50回日本熱帯医学会大会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20091023-20091024
• [Presentation] Positive diversifying selection on Plasmodium falciparum SURFIN_<4.1> (2009)
  • Author(s): Xangsayarath P, Kaewthamasorn M, Yahata K, Nakazawa S, Kaneko O
  • Organizer: The 3rd National Health Research Forum to Support the health research systems strengthening in Lao PDR
  • Place of Presentation: ラオス
  • Year and Date: 20091002-20091003
• [Presentation] マラリア原虫の赤血球侵入・感染赤血球表面の生物学 (2009)
  • Author(s): 金子修
  • Organizer: 第17回分子寄生虫学ワークショップ
  • Place of Presentation: 草津
  • Year and Date: 20090807-20090809
• [Presentation] Plasmodium vivax subtelomeric transmembrane protein 1 (PvSTP1), a homolog of P. falciparum SURFIN ; polymorphism and human sera reactivity. (2009)
  • Author(s): Zhu XT, Sungkapong T, Kaewthamasorn M, Culleton R, Tachibana M, Tsuboi T, Torii M, Yahata K, Cao YM, Chotivanch K, Kaneko O
  • Organizer: Vivax Malaria Research III : 2009 and beyond
  • Place of Presentation: パナマ
  • Year and Date: 20090524-20090528
• [Presentation] The diversity of the extracellular domains of Plasmodium falciparum SURFIN family proteins ; evidence for positive diversifying selection (2009)
  • Author(s): Tang J, Yahata K, Torii M, Kaneko O
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 20090327-20090328
• [Presentation] Characterization of Plasmodium vivax subtelomeric transmembrane protein (PvSTP), a homolog of P. falciparum SURFIN (2009)
  • Author(s): Sungkapong T, Culleton R, Yahata K, Tsuboi T, Torii M, Sattabongkot J, Kaneko O, Chotivanch K.
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 20090327-20090328
• [Presentation] Positive diversifying selection on Plasmodium falciparum SURFIN_<4.2> (2009)
  • Author(s): Kaewthamasorn M, Yahata Y, Alexandre JSF, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 20090327-20090328
• [Presentation] Plasmodium vivax subtelomeric transmembrane protein 1 (PvSTP1), a homolog of P. faiciparum SURFIN, is highly polymorphic (2009)
  • Author(s): Zhu XT, Kaewthamasorn M, Yahata K, Cao YM, Kaneko O
  • Organizer: 43rd Annual U.S.-japan joint Conference of Parasitic Diseases
  • Place of Presentation: 東京
  • Year and Date: 20090107-20090108
• [Presentation] マラリアは世界的な問題だけど、科学はどこまで追い詰めてるの? (2009)
  • Author(s): 金子修
  • Organizer: 第27回日本国際保健医療学会西日本地方会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-28
• [Presentation] マラリア原虫感染赤血球表面分子に対する選択圧 (2008)
  • Author(s): 金子修、Kaewthamasorn M、矢幡一英、Alexandre JSF、中澤秀介、鳥居本美、Sattabongkot J、 Udomsangpetch R
  • Organizer: 第49回日本熱帯医学会大会・第23回日本国際保健医療学会学術大会合同大会
  • Place of Presentation: 東京
  • Year and Date: 20081025-20081026
• [Presentation] Positive diversifying selection on Plasmodium falciparum SURFIN_<4.2> (2008)
  • Author(s): Kaewthamasorn M, Yahata K, Alexandre JSF, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O
  • Organizer: XVIIth International Congress for Tropical Medicine and Malaria
  • Place of Presentation: 韓国
  • Year and Date: 20080929-20081003
• [Presentation] マラリア原虫感染赤血球表面分子に対する選択圧 (2008)
  • Author(s): Kaewthamasorn M,矢幡一英、Alexandre JSF、中澤秀介、鳥居本美、Sattabongkot J、Udomsangpetch R、金子修
  • Organizer: 第16回分子寄生虫学ワークショップ
  • Place of Presentation: 草津
  • Year and Date: 20080803-20080804