Evaluation of the effect of rotavirus vaccine on severe diarrhea and circulating rotavirus strains in Nepal

2011 Fiscal Year Final Research Report

• Project/Area Number: 20406013
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Virology
• Research Institution: Nagasaki University
• Principal Investigator: NAKAGOMI Osamu 長崎大学, 大学院・医歯薬学総合研究科, 教授 (70143047)
• Project Period (FY): 2008 – 2011
• Keywords: ロタウイルス / ワクチン / 遺伝子型 / 分子疫学

Research Abstract

Virtually all children in the world are infected with rotavirus by the age of 5 years, but the outcome of infection differs considerably between developed and developing countries. Nepal is one of such countries where the burden of rotavirus disease is very high. In 2009, the World Health Organization issued a universal immunization of children with rotavirus vaccine, and Nepal is expected to introduce rotavirus vaccine sooner or later. This study revealed a substantial burden of rotavirus and norovirus diarrhea in Nepal, and described the molecular epidemiologic features of these gastroenteritis viruses on which the impact of rotavirus vaccine would be measured. This study also clarified how globally unusual G12P[ 6] rotavirus strains, yet very common in Nepal, evolved over time.

Research Products

• [Journal Article] The occurrence of amino acid substitutions D96N and S242N in VP7 of emergent G2P[ 4] rotaviruses in Nepal in 2004-2005 : a global and evolutionary perspective (2011)
  • Author(s): Doan YH, Nakagomi T, Cunliffe NA, Pandey BD, Sherchand JB, Nakagomi O
  • Journal Title: Arch Virol Volume: 156(11) Pages: 1969-78
• [Journal Article] Global impact of rotavirus vaccines (2010)
  • Author(s): Tate JE, Patel MM, Steele AD, Gentsch JR, Payne DC, Cortese MM, Nakagomi O, Cunliffe NA, Jiang B, Neuzil KM, de Oliveira LH, Glass RI, Parashar UD
  • Journal Title: Expert Rev Vaccines Volume: 9 Pages: 395-407
• [Journal Article] ワクチンによるロタウイルスの感染制御 (2010)
  • Author(s): 中込治, 中込とよ子
  • Journal Title: ウイルス Volume: 60 Pages: 33-48
• [Journal Article] 新時代のワクチン戦略について考える:ロタウイルスワクチン (2010)
  • Author(s): 中込とよ子, 中込治
  • Journal Title: 臨床検査 Volume: 54 Pages: 1392-1399
• [Journal Article] Molecular Epidemiology of Rotavirus Diarrhea among Children Aged<5 Years in Nepal : Predominance of Emergent G12 Strains during 2 Years (2009)
  • Author(s): Sherchand JB, Nakagomi O, Dove W, Nakagomi T, Yokoo M, Pandey BD, Cuevas L, Hart CA, Cunliffe NA
  • Journal Title: J Infect Dis Volume: 200(Suppl) Pages: 182-197
• [Presentation] A global and evolutionary perspective of the G2 VP7 genes of rotavirus strains detected over the last 34 years (2011)
  • Author(s): Nakagomi O, Doan YH, Nakagomi T, Cunliffe NA
  • Organizer: 4th European Rotavirus Biology Meeting
  • Place of Presentation: Reggio Calabria, Italy
  • Year and Date: 20111002-05
• [Presentation] Possible implication of amino acid substitution D96N in the VP7 gene of G2P[ 4] strains emerging in Nepal and elsewhere in the context of the evolution of G2 strains (2011)
  • Author(s): Doan YH, Nakagomi T, Cunliffe NA, Pandey BD, Sherchand JB, Nakagomi O
  • Organizer: XV International Congress of Virology
  • Place of Presentation: Sapporo, Convention Center
  • Year and Date: 20110911-16
• [Presentation] 地球規模で見たロタウイルスG2株の34年間にわたる分子進化学的変遷 (2011)
  • Author(s): 中込治, Doan YH, 中込とよ子
  • Organizer: 第65回日本細菌学会東北支部総会
  • Place of Presentation: 山形市
  • Year and Date: 20110818-19
• [Book] ロタウイルス感染症の世界の状況 (2012)
  • Author(s): 中込とよ子,中込治
  • Total Pages: 10-21
  • Publisher: 医薬ジャーナル社
• [Book] ロタウイルス感染症の医療経済学 (2012)
  • Author(s): 中込治,中込とよ子
  • Total Pages: 120-132
  • Publisher: 医薬ジャーナル社