Physiological status depending on particle size in workers at the nano-handling factor

2010 Fiscal Year Final Research Report

• Project/Area Number: 20406015
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Mie University
• Principal Investigator: ICHIHARA Sahoko Mie University, 大学院・地域イノベーション学研究科, 准教授 (20378326)
• Co-Investigator(Kenkyū-buntansha): HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510) ; ICHIHARA Gaku 名古屋大学, 大学院・医学系研究科, 准教授 (90252238) ; KOBAYASHI Takahiro 東京工業大学, 統合研究院, 特任教授 (50124342) ; OMURA Seiichi 東京工業大学, 統合研究院, ソリューション研究員 (80462480)
• Co-Investigator(Renkei-kenkyūsha): HISANAGA Naomi 愛知教育大学, 保健環境センター, 教授 (90111856) ; SHIBATA Eiji 愛知医科大学, 大学院・医学系研究科, 教授 (90206128)
• Project Period (FY): 2008 – 2010
• Keywords: ナノ粒子 / 循環器疾患 / 心拍数 / リスク評価

Research Abstract

The present study investigated possible respiratory and cardiovascular effects of titanium dioxide on the workers in Shanghai. The present study generated hypotheses that aggregation of particles might reduce nano-scaled particles by an absorption mechanism and that exposure to particle might increase the heart rate in workers handling titanium dioxide.

Research Products

• [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. (2011)
  • Author(s): Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M.
  • Journal Title: Eur J Hum Genet 19(3) Pages: 262-269
  • Peer Reviewed
• [Journal Article] Dose- dependent neurologic abnormalities in workers exposed to 1-bromopropane. (2010)
  • Author(s): Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
  • Journal Title: J Occup Environ Med 52(8) Pages: 769-777
  • Peer Reviewed
• [Journal Article] Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response. (2010)
  • Author(s): Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
  • Journal Title: Arterioscler Thromb Vasc Biol 30(8) Pages: 1553-1561
  • Peer Reviewed
• [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane induced hepatotoxicity (2010)
  • Author(s): Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Sai U, Kitoh J, Ichihara G.
  • Journal Title: Toxicol Sci 115(2) Pages: 596-606
  • Peer Reviewed
• [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters. (2010)
  • Author(s): Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
  • Journal Title: Circ J 74(1) Pages: 163-170
  • Peer Reviewed
• [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains. (2009)
  • Author(s): Liu F, Ichiharhar S, Mohideen SS, Sai U, Kitoh J, Ichihara G.
  • Journal Title: Toxicol Sci 112(1) Pages: 100-110
  • Peer Reviewed
• [Journal Article] Changes in neuro transmitter receptor expression levels in rat brain after 4-week exposure to 1- bromopropane. (2009)
  • Author(s): Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G.
  • Journal Title: Neurotoxicology 30(6) Pages: 1078-1083
  • Peer Reviewed
• [Journal Article] Inhibition of ischemia-induced angiogene sis by benzo [a] pyrene in a manner depen dent on the aryl hydrocarbon receptor. (2009)
  • Author(s): Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
  • Journal Title: Biochem Biophys Res Commun 381(1) Pages: 44-49
  • Peer Reviewed
• [Journal Article] Association of polymorphism of ABCB1 with obesity in Japanese individuals. (2009)
  • Author(s): Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Kojima T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y.
  • Journal Title: Genomics 91(6) Pages: 512-516
  • Peer Reviewed
• [Presentation] The occu pational health survey on workers and nanoparticle numbers in the factory hand ling nano-titanium dioxide. (2011)
  • Author(s): Sahoko Ichihara, Weihua Li, Takahiro Kobayashi, Seiichi Omura, Yusuke Hiraku, Xuncheng Ding, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxico logy
  • Place of Presentation: Washington DC, USA(一般演題)
  • Year and Date: 2011-03-07
• [Presentation] Genomics and proteomics analy sis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of meta bolic syndrome. (2011)
  • Author(s): Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro, Kuzuya, Gaku Ichihara, Sahoko Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA(一般演題)
  • Year and Date: 2011-03-07
• [Presentation] Hyperphosphat emia and hypozincemia affect peripheral nervous system in SHR/NDmcr-cp, a model of meta bolic syndrome. (2011)
  • Author(s): Yuka Suzuki, Sahoko Ichihara, Ai Kato, Takahiro Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA(一般演題)
  • Year and Date: 2011-03-06
• [Presentation] Invo lvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone- depleting solvents. (2010)
  • Author(s): Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi.
  • Organizer: The 6th International Forum on "Oxidative Stress and Aging"
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2010-09-06
• [Presentation] Dose-dependent neuro logic abnor malities in workers exposed to 1-bromo propane. (2010)
  • Author(s): Gaku Ichihara, Weihua Li, Eiji Shibata, Zhijun Zhou, Sahoko Ichihara, Hailan Wang, Qiangyi Wang, Jefe Li, Lingyi Zhang, Yoshihiro Takeuchi, Xuncheng Ding.
  • Organizer: The XII International Congress of Toxicology
  • Place of Presentation: Barcelona, Spain(一般演題)
  • Year and Date: 2010-07-11
• [Presentation] Nrf-2 null mice are more susceptible to 1-bromo propoane-induced hepatotoxicity. (2010)
  • Author(s): Fen Liu, Sahoko Ichihara, S Sheik Mohideen, Ken Itoh, Masayuki Yamamoto, William M Valentine, Gaku Ichihara.
  • Organizer: The 49th Annual Meeting of the Society of Toxico logy
  • Place of Presentation: Salt lake city, USA(一般演題)
  • Year and Date: 2010-03-08
• [Presentation] N-acetyl-L-cysteine preven ts the toxic effects of hyperphosphatemia and hypozincemia on the testicular function in WKY, but not in SHR/NDmcr-cp, a model of metabolic syndrome (2010)
  • Author(s): Yuka Suzuki, Sahoko Ichihara, Ai Kato, Tonomori Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
  • Organizer: The 49th Annual Meeting of the Society of Toxico logy
  • Place of Presentation: Salt lake city, USA(一般演題)
  • Year and Date: 2010-03-08
• [Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Yuji Fujitani, Sahoko Ichihara, Xuncheng Ding, Ying Liu, Qiangyi Wang, Uka Sai, Natsumi Hata, Takahiro Kobayashi.
  • Organizer: The 4th International Conference on Nanotechnology Hel sinki
  • Place of Presentation: Finland(一般演題)
  • Year and Date: 2009-08-27
• [Presentation] Occupational health survey on workers handling titanium dioxide. (2009)
  • Author(s): Sahoko Ichihara, Takahiro Kobayashi, Weihua Li, Xuncheng Ding, Yuji Fujitani, Gaku Ichihara.
  • Organizer: The 29th International Congress of Occupa tional Health
  • Place of Presentation: Cape town, South Africa(一般演題)
  • Year and Date: 2009-03-23
• [Presentation] Dose-dependent neurological and hema tological effects of 1-bromopropane exposure on workers. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
  • Organizer: The 29th International Congress of Occupa tional Health
  • Place of Presentation: Cape town, South Africa(一般演題)
  • Year and Date: 2009-03-23
• [Presentation] Exposure assess ment and health exa mination on workers handling titanium dioxide. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
  • Organizer: The 48th Annu al Meeting of the Society of Toxicology
  • Place of Presentation: Baltimore, USA(一般演題)
  • Year and Date: 2009-03-17
• [Presentation] Inhibition of ischemia-induced angiogenesis by benzo [a] pyrene in a manner dependent on the aryl hydrocarbon receptor. (2009)
  • Author(s): Sahoko Ichihara, Yoshiji Yamada, Gaku Ichihara, Tamie Nakajima, Frank J Gonzalez, Toyoaki Murohara.
  • Organizer: The 48th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Baltimore, USA(一般演題)
  • Year and Date: 2009-03-17
• [Presentation] Ablation of Nrf2 resulted in enhancement of ischemia-induced angiogenesis. (2008)
  • Author(s): Sahoko Ichihara, Gaku Ichihara, Fang Liu, Toyoaki Murohara, Yoshiji Yamada.
  • Organizer: The 81th Scientific Sessions of American Heart Association
  • Place of Presentation: New Orleans, USA(一般演題)
  • Year and Date: 2008-11-09
• [Presentation] Occupa tional Health Survey on workers handling titanium dioxide. (2008)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Qiangyi Wang, Uka Cui, Natsumi Hata, Sahoko Ichihara.
  • Organizer: The 45th Congress of the European Societies of Toxicology
  • Place of Presentation: Greece(一般演題)
  • Year and Date: 2008-10-06
• [Presentation] Research strategy for cardiovascular effects of manu factured nanomaterials. (2008)
  • Author(s): Sahoko Ichihara.
  • Organizer: China-Japan Collaboration Workshop
  • Place of Presentation: Shanghai, China ワークショップ
  • Year and Date: 2008-07-31