International Study of Pokkuri Death Syndrome II-Relationship with Brugada syndrome

2010 Fiscal Year Final Research Report

• Project/Area Number: 20406020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Legal medicine
• Research Institution: Keio University
• Principal Investigator: FUJITA MasakiQ. Keio University, 医学部, 教授 (00211524)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Katsuyuki 群馬大学, 医学部, 客員教授 (10444051) ; OSAWA Motoki 東海大学, 医学部, 教授 (90213686)
• Research Collaborator: SIRISUP Nantana タイ・チュラロンコン大学, 医学部, 准教授 ; MURAKAMI Masami 群馬大学, 医学部, 教授 (30241871) ; BRUGADA Ramon スペイン・ジローナ大学, 医学部, 教授 ; ISLAM Mohammed マレーシア・国立マラ工科大学, 医学部, 教授 ; TAKEUCHI Tsutomu 長崎大学, 熱帯医学研究所, 所長 (00051847) ; NAKANO Takamitsu 群馬大学, 医学部, 非常勤講師
• Project Period (FY): 2008 – 2010
• Keywords: ポックリ病 / Lai-Tai / 突然死 / 冠動脈攣縮 / 動脈硬化 / 不整脈 / Brugada症 / 脂質代謝

Research Abstract

Pokkuri Death Syndrome (PDS) is a sudden unexpected nocturnal death of unknown cause which is known in Japan and other South-Asian countries. We analyzed the autopsy and the background data of sudden death cases in Thailand and identified that such death called Lai-Tai has the same features as PDS in Japan. Lipid analysis of Lai-Tai showed similar tendency as PDS. Genetic analysis of our PDS cases in Japan has shown the possibilities that some cases have the mutation in Brugada syndrome responsible gene, SC5NA.

Research Products

• [Journal Article] Pokkuri Death Syndrome ; sudden cardiac death cases without coronary atherosclerosis in South Asian young males. (2011)
  • Author(s): K.Nakajima, S.Takeichi, Y.Nakajima, M.Q.Fujita
  • Journal Title: Forensic Sci Int 207 Pages: 6-13
  • Peer Reviewed
• [Journal Article] 心臓性突然死"タイのLai-Taiと日本のポックリ病"の比較研究について (2010)
  • Author(s): 藤田眞幸,中嶋克行
  • Journal Title: 医学のあゆみ 235 Pages: 797-799
• [Journal Article] Measurement of serum remnant-like lipoprotein particle-triglyceride (RLP-TG) and RLP-TG/total TG ratio using highly sensitive triglyceride assay reagent. (2010)
  • Author(s): T.Nakano, Y.Tokita, T.Nagamine, A.Tanaka, M.Okazaki S.Yatsuzuka, N.Tarui, Y.Shimomura, Y.Ando, S.Akamatsu, M.Q.Fujita, K.Nakajima
  • Journal Title: Clin Chim Acta 412(1-2) Pages: 71-78
  • Peer Reviewed
• [Presentation] Characteristics of apoB-48 and apoB-100 carrying remnant lipoproteins (RLP) in postprandial plasma. (2009)
  • Author(s): K.Nakajima
  • Organizer: International Symposium on Chylomicrons in Disease.
  • Place of Presentation: Boston Rotterdam, Netherlands
  • Year and Date: 20090602-20090605
• [Presentation] Pokkuri death syndrome and lipoproteins. (2009)
  • Author(s): Nakajima K, Takeichi S, Nakajima Y, Fujita, M
  • Organizer: XVII International Symposium on Atherosclerosis.
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-06-16
• [Remarks] Fujita, MQ, Nakajima K, Takeichi S. Pokkuri Death Syndrome. Update in Forensic Pathology (jointly organized by UiTM and Ministry of Health). Faculty of Medicine, Universiti Teknologi MARA(UiTM) (Shah Aalm, Malaysia, 2009. 9. 8)
• [Remarks] Fujita, MQ, Nakajima K, Takeichi S. Pokkuri Death Syndrome. Special Lecture at Dept.of Forensic Medicine, School of Medicine, Chulalongkorn University (Bangkok, Thailand, 2008. 10. 30)