2010 Fiscal Year Final Research Report
Molecular analyses of G6PD variants in malaria endemic areas in Asian and African countries
| Project/Area Number |
20406023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
MATSUOKA Hiroyuki Jichi Medical University, 医学部, 教授 (10173816)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Makoto 群馬大学, 医学部, 講師 (50326849)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAMOTO Fumihiko 大分大学, 医学部, 教授 (40115556)
MATSUDA Hajime 獨協医科大学, 医学部, 名誉教授 (30114648)
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| Project Period (FY) |
2008 – 2010
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| Keywords | グルコース6リン酸脱水素酵素 / 先天性代謝異常症 / 溶血発作マラリア / プリマキン / 感染蚊対策 / 分子疫学 |
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| Research Abstract |
We visited malaria endemic areas in Asian and African countries to introduce rapid methods for malaria diagnosis and glucose-6-phosphate dehydrogenase (G6PD) activity test. For malaria diagnosis, acridine orange method was employed. For G6PD activity test, WST-8 method was used. These methods were done at the site of malaria endemic areas and results were informed within 30 minutes after taking blood. Patients could receive anti-malarial medicine accordingly including primaquine to eliminate gametocytes. Primaquine was not used for the patients with G6PD deficiency. WST-8 method was useful for the detection of G6PD deficiency in rural areas without electricity and was recommendable for use in malaria control programs. We found more than 700 G6PD deficient people in these activities. DNA analysis of G6PD gene was performed after receiving informed consent. Thus we read about 400 samples and found 22 molecular variants including 5 new G6PD variants.
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[Journal Article] 溶血発作で発症したグルコース6リン酸脱水素酵素異常症の早産児の1例2011
Author(s)
赤澤陽平, 馬場淳, 伊藤有香子, 才田謙, 平林佳奈枝, 三澤由佳, 石田岳史, 服部幸夫, 藤井寿一, 川本文彦, 松岡裕之
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Journal Title
日本未熟児新生児学会雑誌 23(1)
Pages: 108-112
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[Journal Article] Glucose-6-phosphate dehydrogenase (G6PD) variants in three minority ethnic groups in central and northern Vietnam.2009
Author(s)
Hung NM, Matsuoka H, Eto H, Mita T, Tinh TT, Dao LM, Trung PH, Phuong VN, Marma, ASP, Kobayakawa T.
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Journal Title
Trop Med Health 37(1)
Pages: 17-20
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[Journal Article] Fatal Chromobacterium violaceum septicaemia in northern Laos, a modified oxidase test and post-mortem forensic family G6PD analysis.2009
Author(s)
Slesak G, Douangdala P, Inthalad S, Silisouk J, Vongsouvath M, Senguangphachanh A, Moore CE, Mayxay M, Matsuoka H, Newton PN
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Journal Title
Annals Clin Microbiol Antimicrobials 8
Pages: 24
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