2010 Fiscal Year Final Research Report
Use of novel time incorporated Linear Quadratic model and Voronoi diagram for estimation of optimal time-dose-fractionation of radiotherapy
| Project/Area Number |
20500273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Saitama Medical University |
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Principal Investigator |
SEKINE Hiroshi Saitama Medical University, 医学部, 准教授 (40187852)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 放射線生物学 / 直線2次モデル / ボロノイ図 / 生体生命情報学 / 計算幾何学 |
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| Research Abstract |
The important factors of biological effect of radiotherapy are dose per fractionation, fractionation interval and number of fractions. For the purpose of describing the radiobiological effect of radiotherapy, Linear Quadratic model is commonly used in clinical practice. Although this model includes fraction dose and total treatment times as parameters, total treatment time, which is defined by fractionation interval and total number of fractionation, is not included. In this study, time incorporated LQ model has been developed and division cell death along time-course is simulated by Voronoi diagram.
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