2010 Fiscal Year Final Research Report
Analysis of physiological significance of Protocadherin diversity.
| Project/Area Number |
20500287
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
HIRABAYASHI Takahiro Osaka University, 大学院・生命機能研究科, 助教 (40297015)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プロトカドヘリン / ジーンターゲティング |
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| Research Abstract |
The CNR/Protocadherin-alpha genes (Pcdha), which are expressed in the vertebrate brain, encode diverse membrane proteins whose functions are involved in axonal projection. In this study, to elucidate the physiological significance of CNR/Pcdha diversity, we deleted or duplicated the CNR/Pcdha gene cluster in mice. These mice were viable, and did not display any overt abnormalities. The expression level of all the CNR/Pcdha genes was unchanged in the all mutant mice. These results indicate that the Pcdha genes are comprehensively regulated as a cluster unit.
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