2010 Fiscal Year Final Research Report
Control mechanisms of activity in tuberomammillary histaminergic neurons during sleep-waking cycles
| Project/Area Number |
20500288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
TAKAHASHI Kazumi Fukushima Medical University, 医学部, 講師 (90325952)
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| Co-Investigator(Renkei-kenkyūsha) |
KOYAMA Yoshimasa 福島大学, 共生システム理工学類, 教授 (80183812)
KARASHIMA Akihiro 東北大学, 情報科学研究科, 助教 (40374988)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 睡眠 / 覚醒 / 単一ユニット活動 / 視床下部 |
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| Research Abstract |
Unit discharge profiles of several neuronal groups playing important roles in sleep-waking mechanisms were recorded in unanesthetized mice. The finding that, at state transitions, waking-promoting neurons showed activity changes before sleep-promoting neurons did suggests that, not inhibition by sleep-promoting neuron, but disfacilitation of waking-promoting neurons is the primary step of sleep initiation.
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