2010 Fiscal Year Final Research Report
Activation of mesocorticolimbic dopaminergic system by environmental enrichment and trophic factor expression
| Project/Area Number |
20500289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya City University |
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Principal Investigator |
HIDA Hideki Nagoya City University, 大学院・医学研究科, 教授 (00305525)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Keisuke 名古屋市立大学, 大学院・医学研究科, 研究員 (00405177)
FUJITA Masataka 名古屋市立大学, 大学院・医学研究科, 研究員 (10360637)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Keisuke 名古屋市立大学, 大学院・医学研究科, 研究員 (00405177)
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| Research Collaborator |
MASUDA Tadashi 名古屋市立大学, 大学院・医学研究科, 助教 (10423641)
MISUMI Sachiyo 名古屋市立大学, 大学院・医学研究科, 助教 (70529148)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 豊かな環境飼育 / 脳内ドパミン神経系 / ラット / 情動行動 / ドパミン受容体 / 側坐核 / 内側前頭野 / real-time PCR |
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| Research Abstract |
To investigate the function of mesocorticolimbic dopaminergic (DAergic) system in developing rats grown in environmental enrichment (EE), gene expressions of DA receptors and cocaine- and amphetamine-related transcript(CART) and analysis of emotional behavior were carried out. It revealed that expression of DA receptor type IV and CART in prefrontal cortex and amygdala was altered by EE, and also found out that emotional behavior such as anxiety-behavior was reduced in rats grown in EE.
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