2010 Fiscal Year Final Research Report
Molecular mechanisms for regional specification in the retina
| Project/Area Number |
20500299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SAKUTA Hiraki National Institute for Basic Biology, 統合神経生物学研究部門, 助教 (40343743)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 網膜視蓋投射 / CBF2 / 領域特異化 / 網膜 / ニワトリ |
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| Research Abstract |
Misexpression of CBF2 represses the expression of CBF1, GH6, SOHo1, and ephrin-A5, and induces that of EphA3 in the retina. GH6 and SOHo1 repress the expression of CBF2. In contrast to the inhibitory effect of CBF1 on bone morphogenic protein (BMP) signaling, CBF2 does not alter the expression of BMP4 or BMP2. Studies with chimeric mutants of CBF2 showed that CBF2 acts as a transcription repressor in controlling its downstream targets in the retina. Furthermore, Fgf and Wnt first play pivotal roles in inducing the region-specific expression of CBF1 and CBF2 in the optic vesicle.
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