2010 Fiscal Year Final Research Report
Excitatory and Inhibitory synapse distribution on cortical neurons
| Project/Area Number |
20500300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
KUBOTA Yoshiyuki National Institute for Physiological Sciences, 大脳皮質機能研究系, 准教授 (90192567)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 大脳皮質 / 非錐体細胞 / GABA / 3次元再構築 / 樹状突起 / シナプス |
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| Research Abstract |
Understanding the brain's circuit architecture is critical to elucidating its function. Recently, the inhibitory components of cortical circuits have received increased attention. We have found no significant difference of the GABA positive synapse density among different subtype of cortical nonpyramidal cells, although excitatory synapse inputs are found to distribute in different density among cortical nonpyramidal cell subtypes. We also found that excitatory thalamo-cortical afferent fibers are rarely innervated cortical parvalbumin positive cell dendrites and intra-cortical afferent fibers are richly innervated them.
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