Clarification of ATBF1 function in Alzheimer's disease

2010 Fiscal Year Final Research Report

• Project/Area Number: 20500305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute for Longevity Sciences,NCGG
• Principal Investigator: JUNG Cha-Gyun National Institute for Longevity Sciences,NCGG, アルツハイマー病研究部, 室長 (00464579)
• Project Period (FY): 2008 – 2010
• Keywords: アルツハイマー病 / ATBF1 / 神経細胞死 / アミロイドβ / ATM

Research Abstract

We found that ATBF1 expression was up-regulated in the brains of AD and AD model mouse (Tg2576). Moreover, our in vitro studies showed that Aβ and DNA-damaging drugs, namely, etoposide and homocysteine, increased the ATBF1 expression level in primary rat cortical neurons ; this increase, in turn, may activate ATM signaling responsible for neuronal death. In addition, ATBF1 enhanced Aβ production in HEK293T cells transiently cotransfected with ATBF1 and APP via its interaction with APP.

Research Products

• [Journal Article] Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function. (2010)
  • Author(s): Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung CG, Komano H, Michikawa M.
  • Journal Title: J Biol Chem. 285 Pages: 38382-38388
  • Peer Reviewed
• [Journal Article] The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. (2010)
  • Author(s): Kim TS, Kawaguchi M, Suzuki M, Jung CG, Asai K, Shibamoto Y, Lavin MF, Khanna KK, Miura Y.
  • Journal Title: DisModel Mech. 3(11-12) Pages: 752-62
  • Peer Reviewed
• [Journal Article] Honokiol increases ABCA1 expression level by activating retinoid X receptor beta. (2010)
  • Author(s): Jung CG, Horike H, Cha BY, Uhm KO, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo JT, Michikawa M.
  • Journal Title: Biol Pharm Bull. 33(7) Pages: 1105-1111
  • Peer Reviewed
• [Journal Article] Treadmill running improves motor function and alters dendritic morphology in the striatum after collagenase-induced intracerebral hemorrhage in rats. (2010)
  • Author(s): Takamatsu Y, Ishida A, Hamakawa M, Tamakoshi K, Jung CG, Ishida K.
  • Journal Title: Brain Res. 8(1355) Pages: 165-73
  • Peer Reviewed
• [Journal Article] Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy. (2009)
  • Author(s): Kim HJ, Jung CG, Dukala D, Bae H, Kakazu R, Wollmann R, Soliven B.
  • Journal Title: J Neuroimmunol. 29;214(1-2) Pages: 93-100
  • Peer Reviewed
• [Journal Article] Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. (2009)
  • Author(s): Minagawa H, Gong JS, Jung CG, Watanabe A, Lund-Katz S, Phillips MC, Saito H, Michikawa M.
  • Journal Title: J Neurosci.Res. 15;87(11) Pages: 2498-2508
  • Peer Reviewed
• [Journal Article] Targeting of myelin protein zero in a spontaneous autoimmune poluneuropathy.* contributed equally. (2008)
  • Author(s): Kim HJ*, Jung CG*, Jensen MA, Dukala D, Soliven B.
  • Journal Title: J Immunol. 15;181(12) Pages: 8753-60
  • Peer Reviewed
• [Journal Article] Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor betal. (2008)
  • Author(s): Misumi S, Kim TS, Jung CG, Masuda T, Urakawa S, Isobe Y, Furuyama F, Nishino H., Hida H.
  • Journal Title: Eur J Neurosci. 28(6) Pages: 1049-1059
  • Peer Reviewed
• [Journal Article] Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-lalpha. (2008)
  • Author(s): Kim TS, Misumi S, Jung CG, Masuda T, Isobe Y, Furuyama F, Nishino H., Hida H.
  • Journal Title: J Neurosci Res. 86(11) Pages: 2353-2362
  • Peer Reviewed
• [Journal Article] FTY720 modulates human oligodendrocyte progenitor process extension and survival. (2008)
  • Author(s): Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP.
  • Journal Title: Ann.Neurol. 63(1) Pages: 61-71
  • Peer Reviewed
• [Presentation] 多価不飽和脂肪酸餌はLPSで誘導される脳内炎症を抑制する (2010)
  • Author(s): 細野崇、山内玲奈、紺谷昌仙、西辻和親、鄭且均、河島洋、木曽良信、道川誠
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] APP代謝及びAβ産生におけるATBF1の機能解析 (2010)
  • Author(s): 厳景玉、赤津裕康、三浦裕、道川誠、鄭且均
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] APP代謝及びAβ産生機構におけるホメオチィック因子ATBF1の機能解析 (2010)
  • Author(s): 鄭且均、厳景玉、三浦裕、赤津裕康、道川誠
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] ATBF1 interacts with amyloid precursor protein and enhances amyloid β production. (2010)
  • Author(s): Uhm KO, Horike H, Michikawa M, Jung CG.
  • Organizer: International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Honolulu, Hawaii.
  • Year and Date: 2010-07-11
• [Presentation] ATBF1 interacts with amyloid precusor protein and enhances amyloid β protein production. (2010)
  • Author(s): Uhm KO, Horike H, Miura Y, Akatsu H, Michikawa M, Jung CG.
  • Organizer: The First International Conference on Neural Cell Culture (ICNCC 2010).
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2010-06-25
• [Presentation] ATBF1 interacts with amyloid precusor protein and enhances amyloid β protein production. (2010)
  • Author(s): Uhm KO, Horike H, Michikawa M, Jung CG.
  • Organizer: 第2回NAGOYAグローバルリトリート
  • Place of Presentation: 大府
  • Year and Date: 2010-02-26
• [Presentation] Honokiol increases ABCA1 expression level by activating retinoid X receptor beta. (2010)
  • Author(s): Horike H, Jung CG, Cha BY, Uhm KO, Yamauchi R, Yamaguchi T, Hosono T, Woo JT, Michikawa M.
  • Organizer: 第2回NAGOYAグローバルリトリート
  • Place of Presentation: 大府
  • Year and Date: 2010-02-26
• [Presentation] A β enhances the ATBF1 expression responsible for the neuronal cell death. (2009)
  • Author(s): Jung CG, Kawaguchi M, Miura Y, Akatsu H, Hosono T, Uhm KO, Michikawa M.
  • Organizer: International conference on Alzheimer's disease (ICAD)
  • Place of Presentation: Vienna,Austria.
  • Year and Date: 20090712-20090716
• [Presentation] Mechanism underlying apolipoprotein E (ApoE) isoform-dependent HDL generation and impairment of ApoE3-mediated HDL generation by homocysteine. (2009)
  • Author(s): Minagawa K, Gong GS, Akatsu H, Jung CG., Watanabe A, Nishitsuji K, Hosono T, Lund-Katz S, Phillips M C, Komano H, Saito H, Michikawa M.
  • Organizer: International conference on Alzheimer's disease (ICAD).
  • Place of Presentation: Vienna, Austria.
  • Year and Date: 20090712-20090716
• [Presentation] 多価不飽和脂肪酸経口摂取による脳内アミロイドβ蛋白沈着抑制。 (2009)
  • Author(s): 細野崇、西辻和親、紺谷昌仙、鄭且均、河島洋、木曽良信、道川誠
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-20
• [Presentation] The role of ATBF1 in Alzheimer's disease. (2009)
  • Author(s): Jung CG, Kawaguchi M, Miura Y, Akatsu H, Hosono T, Uhm KO, Michikawa M.
  • Organizer: International Society for Neurochemistry (ISN)/Asia-Pacific Society for Neurochemistry (APSN).
  • Place of Presentation: Busan, Korea.
  • Year and Date: 2009-08-24
• [Presentation] Target genes of the transcription factor ATBF1 responsible for the cell-to-extracellular matrix molecules during neuronal differentiation of P19 cells. (2008)
  • Author(s): 三浦裕, Kim TS, Suzuki M, Kawaguchi M, Jung CG., Asai K.
  • Organizer: 第31回日本分子生物学会年会BMB2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] The role of ATBF1 in neurogenesis, cancer and Alzheimer's disease. (2008)
  • Author(s): Jung CG.
  • Organizer: Asia-Korea Conference on Advanced Science and Technology.
  • Place of Presentation: 東京
  • Year and Date: 2008-10-25
• [Presentation] A β enhance the ATBF1 expression responsible for the neuronal cell death. (2008)
  • Author(s): Jung CG, Kawaguchi M, Miura Y, Akatsu H, Yamaguchi T, Horike H, Kim TS, Michikawa M.
  • Organizer: 第51回日本神経化学会総会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] Effect of Angiotensin Converting Enzyme (ACE) on Amyloid-beta (Aβ) metabolism. (2008)
  • Author(s): 阪本崇彰、 鄭且均、 ゾウクン、 道川誠
  • Organizer: 文部科学省科学研究費補助金・特定領域研究「統合脳」5領域夏のワークショップ
  • Place of Presentation: 札幌
  • Year and Date: 2008-08-09
• [Presentation] Regulatory mechanism of the subcellular localization of ATBF1 as a target of ATM/ATR. (2008)
  • Author(s): Miura Y, Kawaguchi M, Kim TS, Shibamoto Y, Jung CG, Khanna KK, Asai K.
  • Organizer: The International Ataxia-Telangiectasia Workshop
  • Place of Presentation: Kyoto.
  • Year and Date: 2008-04-25