2010 Fiscal Year Final Research Report
DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain
| Project/Area Number |
20500314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Nara Medical University |
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Principal Investigator |
TATSUMI Kouko Nara Medical University, 医学部, 講師 (90208033)
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| Co-Investigator(Kenkyū-buntansha) |
AKIO Wanaka 奈良県立医科大学, 医学部, 教授 (90210989)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アストロサイト / コンドロイチン硫酸 / DACS |
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| Research Abstract |
We found a novel CSPG-containing extracellular matrix structure in the adult cerebral cortex and named it Dandelion clock-like structure (DACS) for its morphology reminiscent of dandelion clock. Immunohistochemical analysis showed that DACS is produced by a novel specific subset of astrocytes and is conserved among the species higher than rodents. These findings suggested that DACS participate in higher function of brain.
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