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2010 Fiscal Year Final Research Report

DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain

Research Project

  • PDF
Project/Area Number 20500314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNara Medical University

Principal Investigator

TATSUMI Kouko  Nara Medical University, 医学部, 講師 (90208033)

Co-Investigator(Kenkyū-buntansha) AKIO Wanaka  奈良県立医科大学, 医学部, 教授 (90210989)
Project Period (FY) 2008 – 2010
Keywordsアストロサイト / コンドロイチン硫酸 / DACS
Research Abstract

We found a novel CSPG-containing extracellular matrix structure in the adult cerebral cortex and named it Dandelion clock-like structure (DACS) for its morphology reminiscent of dandelion clock. Immunohistochemical analysis showed that DACS is produced by a novel specific subset of astrocytes and is conserved among the species higher than rodents. These findings suggested that DACS participate in higher function of brain.

  • Research Products

    (6 results)

All 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Localization of chondroitin sulfate proteo-glycan versican in adult brain with special reference to large projection neurons.2008

    • Author(s)
      Horii-Hayashi N, Okuda H, Tatsumi K, Ishizaka S, Yoshikawa M, Wanaka A.
    • Journal Title

      Cell Tissue Res. 334(2)

      Pages: 163-177

    • Peer Reviewed
  • [Journal Article] DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain.2007

    • Author(s)
      Tatsumi K, Hayashi N, Okuda H, Yoshikawa M, Ishizaka S, Miyata S, Manabe T, Wanaka A.
    • Journal Title

      Biochem.Biophis.Res.Commun. 364(2)

      Pages: 410-415

    • Peer Reviewed
  • [Presentation] DACS, a novel matrix structure composed of chondroitin sulfate proteo- glycan in the brain.2008

    • Author(s)
      辰巳晃子、堀井-林謹子、奥田洋明、和中明生
    • Organizer
      第51回日本神経化学会総会(シンポジウム)
    • Place of Presentation
      富山
    • Year and Date
      20080000
  • [Presentation] DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain.2008

    • Author(s)
      辰巳晃子・林 謹子、奥田洋明、宮田清司、眞部孝幸、和中明生
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      20080000
  • [Presentation] 成熟脳の新しい細胞外基質構造DACSについて2007

    • Author(s)
      和中明生、辰巳晃子、堀井-林謹子、奥田洋明
    • Organizer
      第313回大阪大学神経科学懇話会
    • Place of Presentation
      大阪
    • Year and Date
      20070000
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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